Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/73020
Title: | Determination of Uncojugated and total Ezetimibe in Human Plasma and its Application to Pharmacokinetic Studies |
Researcher: | Gaikwad Poonam Vithal |
Guide(s): | Bhoir Suvarna Indravadan |
Keywords: | Acetonitrile Bioequivalence Calibration Curve Carryover Effect EZM Matrix Effect Pharmacokinetics Physicochemical |
University: | Narsee Monjee Institute of Management Studies |
Completed Date: | |
Abstract: | The pharmacological response is generally related to the concentration of drug newlineat receptor site (Guidance for Industry: Bioavailability and Bioequivalence Studies for Orally Administered Drug Products-General Considerations, USFDA, 2003).The newlineavailability of a drug from the dosage form is a critical element of drug efficacy (Guidelines for Bioavailability and Bioequivalence Studies, CDSCO, 2005). newlineHowever, drug concentrations usually, cannot be readily measured directly at the site of action; therefore most bioavailability studies involve the determination of drug concentration in the biological matrix like blood, plasma, urine etc. This is based on the premise that the drug at the site of action is in equilibrium with drug in blood. It is therefore possible to obtain an indirect measure of drug response by monitoring drug level in biological matrix. The bio-analysis employed for the quantitative newlinedetermination of drug and metabolites in biological fluids plays a significant role in the evaluation of bioequivalence, pharmacokinetic and toxicological studies. |
Pagination: | |
URI: | http://hdl.handle.net/10603/73020 |
Appears in Departments: | Department of Chemical Sciences |
Files in This Item:
File | Description | Size | Format | |
---|---|---|---|---|
00. title page.pdf | Attached File | 35.89 kB | Adobe PDF | View/Open |
01. declaration by the student.pdf | 5.51 kB | Adobe PDF | View/Open | |
02. certificate.pdf | 5.39 kB | Adobe PDF | View/Open | |
03. acknowledgements.pdf | 8.2 kB | Adobe PDF | View/Open | |
04. list of contents.pdf | 30.23 kB | Adobe PDF | View/Open | |
05. list of abbreviations & symbols.pdf | 78.68 kB | Adobe PDF | View/Open | |
06. list of figures.pdf | 81.07 kB | Adobe PDF | View/Open | |
07. list of tables.pdf | 30.22 kB | Adobe PDF | View/Open | |
08. chapter 1.pdf | 240.08 kB | Adobe PDF | View/Open | |
09. chapter 2.pdf | 223.45 kB | Adobe PDF | View/Open | |
10. chapter 3.pdf | 1.13 MB | Adobe PDF | View/Open | |
11. chapter 4.pdf | 1.49 MB | Adobe PDF | View/Open | |
12. chapter 5.pdf | 1.87 MB | Adobe PDF | View/Open | |
13. chapter 6.pdf | 126.66 kB | Adobe PDF | View/Open | |
14. reference.pdf | 225.39 kB | Adobe PDF | View/Open |
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