GENETIC STUDIES ON GONADOTROPIN REGULATING GENE S POLYMORPHISMS AND ITS ASSOCIATION WITH POLYCYSTIC OVARY SYNDROME

Abstract

Polycystic Ovary Syndrome is a heterogeneous endocrine disorder of women It was initially described as an association of polycystic ovaries with amenorrhea hirsutism and obesity in women presented with infertility Though the direct cause of PCOS remains unknown both environmental and genetic factors are implicated Considering the significance of hypothalamus pituitary gonadal axis on the female reproductive physiology and reported clinical phenotypes of PCOS thirteen SNPs on five candidate genes involved in the above axis was examined of which GnRH1rs6185 LHand#946; rs1800447 rs34349826 rs5030774 FSHR rs132905 rs6165 SHBG rs9913778 rs6258 rs6259 AR rs5919393 rs5919411 rs12014709 did not show any association with PCOS however SNP rs6166 in FSHR shown to be protect the individual from developing in to PCOS A lack of association of other SNPs with PCOS does not imply a weakness in the study However probably a huge sample size and more SNPs in other candidate genes might provide additional information on this important area newline