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http://hdl.handle.net/10603/7113
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DC Field | Value | Language |
---|---|---|
dc.coverage.spatial | Biochemistry | en_US |
dc.date.accessioned | 2013-02-27T06:49:12Z | - |
dc.date.available | 2013-02-27T06:49:12Z | - |
dc.date.issued | 2013-02-27 | - |
dc.identifier.uri | http://hdl.handle.net/10603/7113 | - |
dc.description.abstract | The cuttlefish liver discarded during processing contains a high oil content (6- 40%) and is a rich source of and#969;-3 polyunsaturated fatty acids (and#969;-3 PUFAs) like eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA). Feeding cuttlefish liver oil (CFLO) at 1% level to rats fed atherogenic diet (AD) for a period of 90 days, showed a lowering of gain in body weight and liver weight; lipid components in serum and tissues, LDL-cholesterol (LDL-C) and atherogenic ratio; increase in HDL-cholesterol (HDL-C), increased faecal excretion of bile acids and neutral sterols; decreased lipogenic enzyme activities, increased antioxidant enzyme activities and antioxidant levels, but, decreased levels of lipid peroxidation products in tissues. The antiatherogenic action of CFLO observed is through decreased lipogenesis, increased cholesterol transport to liver, enhanced excretion of neutral sterols and bile acids and above all a stimulated antioxidant defense system and this might be due to its high content of and#969;-3 PUFAs which in the presence of antioxidants (vitamins E and C and green tea flavonoids) offer greater effect. The cardioprotective action, immune function, inflammatory response and platelet aggregation was also studied by feeding 1 % CFLO for a period of 45 days. The study showed lowering of the levels of diagnostic marker enzymes, enhanced proliferation of spleen and bone marrow cells, increase in the number of plaque forming cells in the spleen and antibody titre in the circulation; inhibition of carrageenan induced acute paw oedema, formalin induced chronic paw oedema and adenosine diphosphate (ADP) induced platelet aggregation. The and#969;-3 PUFAs especially the EPA present in the CFLO may be responsible for the observed beneficial effects. | en_US |
dc.format.extent | 150p. | en_US |
dc.language | English | en_US |
dc.relation | - | en_US |
dc.rights | university | en_US |
dc.title | Biological effects of feeding cuttle fish liver oil to rats | en_US |
dc.title.alternative | - | en_US |
dc.creator.researcher | Joseph, Sophia Margaret | en_US |
dc.subject.keyword | immune function | en_US |
dc.subject.keyword | cuttlefish liver oil | en_US |
dc.subject.keyword | atherogenesis | en_US |
dc.subject.keyword | eicosapentaenoic acid | en_US |
dc.subject.keyword | docosahexaenoic acid | en_US |
dc.subject.keyword | cardioprotective | en_US |
dc.subject.keyword | Biochemistry | en_US |
dc.description.note | References p.122-150 | en_US |
dc.contributor.guide | Sherief, P M | en_US |
dc.contributor.guide | Nair, J Rajasekharan | - |
dc.publisher.place | Kottayam | en_US |
dc.publisher.university | Mahatma Gandhi University | en_US |
dc.publisher.institution | School of Bio Sciences | en_US |
dc.date.registered | n.d. | en_US |
dc.date.completed | July, 2007 | en_US |
dc.date.awarded | n.d. | en_US |
dc.format.dimensions | - | en_US |
dc.format.accompanyingmaterial | None | en_US |
dc.type.degree | Ph.D. | en_US |
dc.source.inflibnet | INFLIBNET | en_US |
Appears in Departments: | School of Bio Sciences |
Files in This Item:
File | Description | Size | Format | |
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01_title.pdf | Attached File | 25.36 kB | Adobe PDF | View/Open |
02_dedication.pdf | 24.38 kB | Adobe PDF | View/Open | |
03_declaration.pdf | 21.34 kB | Adobe PDF | View/Open | |
04_certificate.pdf | 22.41 kB | Adobe PDF | View/Open | |
05_acknowledgements.pdf | 24.03 kB | Adobe PDF | View/Open | |
06_abbreviations.pdf | 33.62 kB | Adobe PDF | View/Open | |
07_abstract.pdf | 29.44 kB | Adobe PDF | View/Open | |
08_contents.pdf | 22.52 kB | Adobe PDF | View/Open | |
09_list of tables.pdf | 32.48 kB | Adobe PDF | View/Open | |
10_list of figures.pdf | 30.7 kB | Adobe PDF | View/Open | |
11_chapter 1.pdf | 381 kB | Adobe PDF | View/Open | |
12_chapter 2.pdf | 144.5 kB | Adobe PDF | View/Open | |
13_chapter 3.pdf | 611.34 kB | Adobe PDF | View/Open | |
14_chapter 4.pdf | 90.47 kB | Adobe PDF | View/Open | |
15_chapter 5.pdf | 99.84 kB | Adobe PDF | View/Open | |
16_chapter 6.pdf | 71.65 kB | Adobe PDF | View/Open | |
17_summary.pdf | 49.04 kB | Adobe PDF | View/Open | |
18_references.pdf | 340.88 kB | Adobe PDF | View/Open |
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