Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/68324
Title: Drug nutrient interactions with special reference to heroin and carotene functions in albino rats
Researcher: Saha, Prem Kishore
Guide(s): Goswami, Umesh C
Keywords: Albino
and#946;-Carotene
Antioxidants
Drowsiness
Haemoglobin
Heroin
Opium
Piloerection
University: Gauhati University
Completed Date: 31/12/2002
Abstract: Heroin is the most widely used opium, probably because of its potency and high lipophilicity, which affords rapid brain access. It is rapidly biotransformed, by a hydrolytic process, to 6- MAM and then more slowly to morphine by blood and various tissues in the body, including the brain (Nakamura et al., 1975). Heroin is a central nervous system affecting, psychotropic, neuro-toxic, and is a potent agonist drug with a high addiction liability. Prolonged heroin use can cause respiratory diseases, pulmonary oedema, bradycardia, arryhythmias and hypothermia (Wills, 1994). and#946;- Carotene being antioxidants, scavengers of singlet oxygen, antimutagenic and above all anticarcinogenic and immunomodulator nutrient (Tschanz et al., 1996) may provide ample scope in preventing different adverse effects of heroin. Considering the manifold activities and regulations through and#946;-carotene, the present experiments have been designed to investigate whether the toxic and other adverse effects of heroin can be ameliorated through the interactions of heroin with and#946;- carotene. Experimental Design: Young adult albino rats weighing about 100-120 gm were taken for the experiments and were divided into three groups: Group I, II, and III. Each group was further divided into seven sub-groups namely A, B, C, D, E, F, and G containing six rats each. The treatment of different sub-groups was as follows: Sub-group Treatment A Control feeding B Oil feeding C and#946;- Carotene D and#946;- Carotene + Heroin (LD25) E and#946;- Carotene + Heroin (LD25) F Heroin (LD25) G Heroin (LD50) The heroin treatment was given through intra-muscular injection in alternate days whereas and#946;-carotene was given through oral feeding daily. The rats of Group I, II, and III were treated with heroin for 4, 6, and 7 weeks respectively. The content of the thesis has been illustrated in the course of nine chapters; each chapter containing an introduction, aims of the experiment, methods, results, discussion, and summary separately. Chapter 1: This Chapter includes general introduction and aims of the
Pagination: 
URI: http://hdl.handle.net/10603/68324
Appears in Departments:Department of Zoology

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01_title page.pdfAttached File18.18 kBAdobe PDFView/Open
02_certificate.pdf32.54 kBAdobe PDFView/Open
03_acknowledgement.pdf67.85 kBAdobe PDFView/Open
04_abstract.pdf108.72 kBAdobe PDFView/Open
05_content.pdf20.47 kBAdobe PDFView/Open
06_chapter 1.pdf946.13 kBAdobe PDFView/Open
07_chapter 2.pdf168.15 kBAdobe PDFView/Open
08_chapter 3.pdf1.81 MBAdobe PDFView/Open
09_chapter 4.pdf2.25 MBAdobe PDFView/Open
10_chapter 5.pdf577.08 kBAdobe PDFView/Open
11_chapter 6.pdf627.02 kBAdobe PDFView/Open
12_chapter 7.pdf1.08 MBAdobe PDFView/Open
13_chapter 8.pdf1.85 MBAdobe PDFView/Open
14_general discussion.pdf831.76 kBAdobe PDFView/Open
15_references.pdf852.31 kBAdobe PDFView/Open
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