Role of HSPA8 in pathological outcomes in the host during malaria

Abstract

Hemolytic diseases like malaria encompass a group of disorders characterized by hemolysis or accelerated destruction of red blood cells (RBCs). Hemolysis leads to the release of Hemoglobin and its derived products like methemoglobin, free heme, hematin, and hemin in the plasma. Although normal hemin levels are crucial for governing many physiological processes, hemin accumulation to abnormal levels is highly toxic to the corresponding cells, tissue, or organs and contributes to the various pathological outcomes of malaria. newline