Catalytic multi taking organoselenium antioxidants

Abstract

This thesis incorporates the synthesis and evaluation of antioxidant properties of organoselenium compounds. The synthesized compounds were characterized using various techniques such as 1H, 13C{1H} and 77Se{1H} NMR and HRMS spectroscopy. Some of the compounds were also characterized by X-ray single crystal analysis. Their antioxidants activities were evaluated using thiophenol assay. Mechanistic studies were conducted to propose the catalytic mechanisms for the GPx-like activity of organoselenium compounds utilizing 77Se{1H} NMR mechanistic experiments. The synthesis, reaction of bis(3-amino-1-hydroxybenzyl) diselenide containing two ortho groups to the Se-atom was carried out. Also, their antioxidants and antibacterial properties were examined. Benzamide derived benzoselenazoles exhibited potent pancreatic lipase inhibitor activity in addition to antioxidant properties. Furthermore, o/p-hydroxy substituted benzoselenazoles antioxidant properties have been assessed using thiophenol assay and azo-initiated cumene autoxidation in the homogeneous phase. These also exhibited antibacterial properties against Bacillus subtilis as well as Pseudomonas aeruginosa biofilms. In general, the study emphasises the synthesis of novel antioxidants with fascinating biological prospective. Such antioxidants may be useful as therapeutics in diseases caused by oxidative stress through reducing the adverse effects of reactive oxygen species. newline