Simulation and Modeling of TFET based Biosensors for Label Free Detection of Breast Cancer Biomolecules

Abstract

The vital widespread application of biosensors in different clinical and non-clinical domains leads to more research interest in designing and developing next-generation biosensors that can serve as point-of-care testing tools (PoCT). These PoCT tools deliver fast detection results with simple operation compared to conventional laboratory based newlinemethods which are highly cost effective and time-consuming. Among various newlinebiosensors, FET-based biosensors have become popular with their simple operation, newlineportable size, compatibility with standard CMOS technology, and the possibility for newlinethe label-free detection of target biomolecules using the dielectric modulation (DM) technique. The Tunnel FET device emerges as the potential candidate to suppress the newlinelimitation of conventional FET-based biosensors. The superior subthreshold characteristics and unique band-to-band tunneling of charge carriers made the TFET the potential candidate for designing the next-generation biosensor. In this work, a complete comprehensive investigation of the method and technique to use the TFET device for the label-free detection of Breast Cancer Cells (BCC) based on their dielectric constant value has been provided. The development of cancerous tumors in the breasts of females is the cause of breast cancer, which is one of the most common forms of cancer that affects women across the world. In the year 2022, worldwide 11.7% of all cancers diagnosed, and 6.9% of all deaths attributable to cancer were documented are associated with this condition. A comprehensive review work is carried out on breast cancer detection using TFET devices to thoroughly analyze the detection methods and physical design approaches to provide information about TFET based biosensors for BCC detection at a single point. Indeed, an in-depth analysis of all TFET based biosensors for detecting a range of target biomolecules has been conducted, encompassing sensitivity parameters and device design techniques. A new kind of Z-shaped gate TFET biosensor with the split drain