Design and development of tumour targeted nanoconstructs of  docetaxel

Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/599574

Title:	Design and development of tumour targeted nanoconstructs of docetaxel
Researcher:	Joga Singh
Guide(s):	Kaur, Indu Pal and Bhatia, Alka
Keywords:	Bioavailability Cancer Cell Cross Talk Lipidic Nanoparticles Peptide Ligands Safety and Stability
University:	Panjab University
Completed Date:	2023
Abstract:	The present work describes encapsulation of docetaxel and curcumin in solid lipid nanoparticles (DCLEN) with high active payload, improved stability and bioavailability. Further we developed a theranostic platform (therapeutic + diagnostic) by conjugating DLEN with QDs, which was surface-decorated with a peptide ligand to impart targetability to the system (QDSLNs-P). The formed nano platform exhibited complete regression of DMBA-induced breast cancer in rats and exhibited improved maximum tolerated dose. newline
Pagination:	xvii, 235p.
URI:	http://hdl.handle.net/10603/599574
Appears in Departments:	University Institute of Pharmaceutical Sciences

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File	Description	Size	Format
01_title.pdf	Attached File	117.38 kB	Adobe PDF	View/Open
02_prelime pages.pdf		2.59 MB	Adobe PDF	View/Open
03_introduction.pdf		1.31 MB	Adobe PDF	View/Open
04_plan of work.pdf		119.42 kB	Adobe PDF	View/Open
05_chapter1.pdf		1.43 MB	Adobe PDF	View/Open
06_chapter2.pdf		3.11 MB	Adobe PDF	View/Open
07_chapter3.pdf		2.4 MB	Adobe PDF	View/Open
08_chapter4.pdf		1.09 MB	Adobe PDF	View/Open
09_annexures.pdf		22.43 MB	Adobe PDF	View/Open
80_recommendation.pdf		1.18 MB	Adobe PDF	View/Open

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