Shodhganga : a reservoir of Indian theses @ INFLIBNET
The Shodhganga@INFLIBNET Centre provides a platform for research students to deposit their Ph.D. theses and make it available to the entire scholarly community in open access.
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/599574
| Title: | Design and development of tumour targeted nanoconstructs of docetaxel |
| Researcher: | Joga Singh |
| Guide(s): | Kaur, Indu Pal and Bhatia, Alka |
| Keywords: | Bioavailability Cancer Cell Cross Talk Lipidic Nanoparticles Peptide Ligands Safety and Stability |
| University: | Panjab University |
| Completed Date: | 2023 |
| Abstract: | The present work describes encapsulation of docetaxel and curcumin in solid lipid nanoparticles (DCLEN) with high active payload, improved stability and bioavailability. Further we developed a theranostic platform (therapeutic + diagnostic) by conjugating DLEN with QDs, which was surface-decorated with a peptide ligand to impart targetability to the system (QDSLNs-P). The formed nano platform exhibited complete regression of DMBA-induced breast cancer in rats and exhibited improved maximum tolerated dose. newline |
| Pagination: | xvii, 235p. |
| URI: | http://hdl.handle.net/10603/599574 |
| Appears in Departments: | University Institute of Pharmaceutical Sciences |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 01_title.pdf | Attached File | 117.38 kB | Adobe PDF | View/Open Request a copy |
| 02_prelime pages.pdf | 2.59 MB | Adobe PDF | View/Open Request a copy | |
| 03_introduction.pdf | 1.31 MB | Adobe PDF | View/Open Request a copy | |
| 04_plan of work.pdf | 119.42 kB | Adobe PDF | View/Open Request a copy | |
| 05_chapter1.pdf | 1.43 MB | Adobe PDF | View/Open Request a copy | |
| 06_chapter2.pdf | 3.11 MB | Adobe PDF | View/Open Request a copy | |
| 07_chapter3.pdf | 2.4 MB | Adobe PDF | View/Open Request a copy | |
| 08_chapter4.pdf | 1.09 MB | Adobe PDF | View/Open Request a copy | |
| 09_annexures.pdf | 22.43 MB | Adobe PDF | View/Open Request a copy | |
| 80_recommendation.pdf | 1.18 MB | Adobe PDF | View/Open Request a copy |
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