Development and Evaluation of a New Interpenetrating Polymer Network study for Controlled Release of Antihypertensive Drugs

Abstract

Pharmaceutical field is the research and development intensive field. The search for safe and effective drugs continues to be major effort involving the pharmaceutical industries, universities and government. The complexities of discovering and testing new drugs have become enormous as a result of the many aspects of safety, efficacy and economics that determine acceptability of a drug. Indeed the situation as a whole has become almost a Gordian knot. The concept of controlled drug delivery has been embraced with great enthusiasm by many as the sword that will slice through Gordian knot. Administration of drugs in conventional manner is not free from newlinetoxicity and G.I. tract related problems. Also hepatic metabolism reduces bioavailability of drug and to initiate and sustained therapeutic action higher doses of drug is needed. Only I/V dreeps can solve the above problem, however continuous presence of needle in the circulatory portal is inconvenient to patient. Ultimately patient compliance is reduced, and management of disease suffers. The present study was aimed at the development of (Part I) Interpenetrating polymer networks of chitosan and guar gum by using Propranolol HCl as a model drug, (Part II) Interpenetrating polymer networks of chitosan and hydroxy ethyl cellulose by using Diltiazem HCl as model drug, (Part III) Interpenetrating Polymers network of hydroxy ethyl cellulose as well as poly acrylic acids with using Verapamil HCl as a model drug. It also be concluded that, the Diltiazem HCl microspheres formulation (ODB) might be successful preference as a anti hypertensive drug. Satisfactory results were found from evaluation of various parameters such as flow property, drug content uniformity, % yield value, % DEE, particle size in vitro dissolution study, swelling index and kinetic study. Therefore, the developed formulations be able to be considered as one of the capable formulations method of Interpenetrating polymer networks in the management of hypertension. newline