Design Development and Evaluation of bi layer Tablet Containing Ziprasidone Hydrochloride

Abstract

Current work involves designing and development of Ziprasidone hydrochloride newlinebi-layer tablets. BCS Class II drug compound. Ziprasidone hydrochloride, a newlinenewer antipsychotic, treats positive and negative schizophrenia symptoms. newlineSchizophrenia patients require antipsychotics with quick and delayed release. newlineBoth actions are unformulated. A Ziprasidone hydrochloride bilayer tablet newlinedelivers the medicine quickly and slowly for long-term usage. As a bilayer newlineTablet, one layer released the medication swiftly for immediate effect and the newlineother slowly to maintain drug concentration in the sick patient. Factorial newlineexperiments using one, two, three, or more components. Simple comparison newlineexperiments include one element. These analyses used t-tests or ANOVA. newlineFactorial studies using two components (A and B) use two-level factorial designs newlineto determine how they affect the response variable. This is done by considering newlineall factor level combinations. Ziprasidone Hcl was created utilizing State ease newlinepreliminary Plan Master programming. Specifically, a 1 element central newlinecomposite design (CCD) was used. Both HPMC K 4M (X1) and Eudragit RLPO, newlineRSPO (X2) were examined at three levels in the review. The factor effect is the newlineresponse variable change caused by changing the factor level. Complex factorial newlineexperiments with several components (A, B... K) with two levels (quotlowquot and newlinequothighquot) might be difficult. Ziprasidone hcl was found to be pure after testing. newlineThis was established via testing. According to the investigation, the drug sample newlineis appropriate for further testing. An organoleptic test confirmed the aroma was newlineperfume, which is acceptable to the Indian pharmacopoeia. Monograph newlinelimitations for Ziprasidone hcl melting point were 274-2760C. The experiment newlineshowed that Ziprasidone HCL was soluble in hydrochloric acid, DMSO, ethanol, newlinemethanol, and NaOH. The UV absorption spectra of ziprasidone hydrochloride newlinerevealed a and#955;max of 317.47 nm. A UV-Visible spectrophotometer was used to newlineconstruct a calibration curve in methanol, encompassing a concent