Isolation Purification of Bioactive Compound from Glycosmis Pentaphylla and its Anticancer Propertyand Molecular Docking Approach

Abstract

Two of the biggest issues facing humanity are climate change and human health. Sustainable, natural, and eco-friendly solutions to such global problems have attracted a lot of interest and continue to do so. Nowadays, cancer is also becoming one of the life threatening diseases which affects both male and female. The modalities rate is increased day by day. Nature give as gift of natural resource using mankind for daily needs for human health care (Rahman et al., 2018; Dwivedi et al., 2022; Hansen et al., 2017). The medicinal plants mainly attributed to secondary metabolites i.e., terpenes, 93 phenolics, alkaloids, steroids, and flavonoids (Bachheti et al., 2022; Céspedes-Méndez et al., 2021; Shazhni et al., 2018) it might be synthesize with the help of inorganic precursors by plants. Currently, scientifically growing great attention in isolation of bioactive compounds from plants and its biological activities. Therefore, the alternative needs and sources are considered to pharmaceutical industry approaches. Significantly, vast availability of plant based drugs are highlighted (Gulcin, 2020; Atanasov et al., 2015; Mohammadinejad et al., 2016). Currently, a natural product or a natural product analogue is present in practically every pharmacological type of drug. The study of higher plants has resulted in the discovery of numerous novel medications. Only a small part of higher plants have been studied thus far. As a result, there is a vast pool of relevant chemical substances that can be used as both medications and models for synthetic analogies. G. pentaphylla mainly distributed in India, China, and several subtropical regions. Treatments include cold, body temperature rising, inflammation, bronchitis, diabetes, cancer, and chronic diseases such as rheumatism, bronchitis, and rheumatism (Fathi et al., 2022). They are divided into several categories, including essential oils, organic acids, terpenoids, glycosides, saponins, tannins, alkaloids, phenolic chemicals, steroids, resins, and others are produced by the g