Vitamin D receptor gene polymorphisms VDR and steroid receptor status in breast cancer patients

Abstract

newlineBreast cancer ranks as the foremost prevalent cancer worldwide, and a newlinerising burden has been associated with it for the past couple of years. In India, every newlineyear, approximately there are 100,000 new breast cancer diagnoses. A receptor for newlineVitamin D (VDR), belonging being a family of nuclear receptors for steroid newlinehormones, contributes a key role in the biological function of calcitriol, an active form newlineof vitamin D. Several Epidemiological studies have shown associations between newlinebreast cancer and the VDR gene polymorphisms, yet no conclusive results were newlineobtained. Also, apart from these studies, the role of VDR gene polymorphisms in newlinerelation to steroid receptor (estrogen and progesterone) status is still limited