Design Synthesis and Biological Evaluation of 4 Phenyl 1 3Thiazole Substituted Imidazolidin 4 One Derivatives through QSAR Modeling Molecular Docking and Dynamic Studies as Potential Aurora Kinase Inhibitors

Abstract

Cancer has emerged as a deadliest disease, and the different types of cancer such newlineas lung, stomach, breast, and prostate cancer are life-threatening. Breast cancer has surpassed newlinelung cancer in its incidence. The causative factors include family history, age, lifestyle newlinedisorders such as obesity, physical inactivity etc., where in approximately 75% is due to newlinethe expression of cancer newlineAnastrazole, Letrazole and Exemestane are some of the aromatase inhibitors newlinein the market. Irosustat (BN-83495 or STX-64), is a clinical candidate with success rate newlinefrom Phase I to Phase II clinical trials where it is discontinued. It is an orally active, newlineirreversible non- steroidal inhibitor. Amidst proving to be a better inhibitor, to date no newlineclinical drug of Steroidal sulfatase inhibitors are available in the market newline