Luminescent X ray Visible Magnetic Multifunctional Metal Organic Frameworks MOFs with Complimenting Drug Polyelectrolyte Complex for Therapeutic Applications

Abstract

Metal organic frameworks (MOFs) is a class of coordination polymers newlinewhich have found unparalleled growth in recent years due to their newlinedistinguished features, unique functionalities and ever-expanding newlinecombinations of metal ions and ligands. Multifunctional MOFs, due to their newlinehigh degree of functionality, ease of synthesis by self-assembly as well as newlinepre- and post-synthetic modification procedures, play a crucial role in newlinecontemporary research especially in the development of advanced newlinefunctional materials. In the present study, versatile combinations of newlinemultifunctional MOFs holding luminescence, X-ray visibility, magnetic newlineproperty and antibiofilm activity have been developed for diverse newlinefunctional applications. In the first part of the study, a silver cluster infused newlinesilver MOF with long lived green emission in millisecond range newlinecomplemented with antibacterial and biofilm inhibition property has been newlinesynthesized. Diverse functional materials such as luminescent films, thin newlinefilm coatings and hydrogels were also derived from this silver MOF with newlinethe assistance of polymers; poly(methyl methacrylate), poly(vinyl alcohol) newlineand poly(caprolatone). Novel therapeutic approaches aim at integration of newlineimaging and treatment in a single system especially for cancer diagnosis newlineand therapy. In the second part of the study a combinatorial nanotheranostic newlinecomposite system has been developed in situ from bismuth MOF and iron newlineoxide which exhibits both magnetic and inherent radiopaque features for image guided magnetic hyperthermia therapy. The third section comprises newlinedevelopment of a novel bisphosphonate - radiopaque bismuth MOF newlinecombinatorial drug delivery system exploring the intrinsic drug loading and release potential of MOFs. Biofunctional investigation validates newlinecytocompatibility (rat bone marrow stem cells) and action of the assynthesized bisphosphonate on osteoclast precursor cells RAW 264.7, newlinethereby its role in inhibiting osteoclast activity which is responsible for newlinebone resorption. newline