Phenolic and aminic organochalcogen antioxidants synthesis and evaluation of antioxidant properties

Abstract

This thesis incorporates the synthesis and evaluation of antioxidant properties of phenolic and aminic organochalcogen compounds. Their antioxidants activities were evaluated using thiophenol and coupled-reductase assay. Catalytic mechanisms for the GPx-like activity of organoselenium compounds were proposed utilizing 77Se{1H} NMR mechanistic insights. Bis-naphthol based antioxidants demonstrated significant antibacterial properties. Diarylamine based antioxidants exhibited potent antiferroptotic activity. Furthermore, a cyclic diselenide containing BODIPY-based fluorescent probe was synthesized that showed high sensitivity and selectivity for H2O2 and t-BuOOH. Overall, the research highlights the development of novel antioxidants with promising biological applications and could be considered for therapeutic strategies in treating diseases associated with oxidative stress. newline