Assessment of the Nephroprotective Potential of Pongamia Pinnata

Abstract

newline Background and Aim: Pongamia pinnata (L.) Pierre tree has long been utilised in India and its adjacent countries for its traditional medicinal properties. It belongs to the family Leguminosae. The present study examined the effect of flowers, seeds and leaves extract of Pongamia pinnata against STZ induced nephropathy. newlineMaterials and Methods: Thrity male wistar albino rats were randomly divided into six groups to which five rats in each cage. I group received normal saline and group II administered HFD and low dose of STZ inj. 35 mg/kg i.p. Groups III and IV treated with ethanol extract of PP flowers and Groups V and VI receiving PP leaves extract at a dose of 250 mg/kg body weight and 500 mg/kg. respectively. The fasting blood glucose, hematological parameters, biochemical estimations acute toxicity and histopathological examination were analyzed and comparison was done against STZ induced nephrotoxicity in rats. newlineResults: The oral administration of ethanolic flowers and leaves extract of PP at a doses of 250 mg/kg b.wt/ and 500 mg/kg for 28 days exhibited a significant reduction in the levels of blood glucose, body weight, urea, uric acid and creatinine, UAE compared to STZ treated rats whereas increase the levels of blood hematological parameters (Hb., PCV, PLC, MCH, MCHC). The renal marker of kidney and histopathological parameters were changed significantly in STZ treated rats. Treatment with ethanolic extract of flowers and leaves of Pongamia pinnata restored the above altered parameters significantly. newlineConclusion: The extract of leaves of PP showed a more efficient antinephrotoxic effect compared to the flowers extract of PP. newlineKeywords: Nephropathy, high-fat diet, hyperglycemia, streptozotocin, Pongamia pinnata.