Design and development of selected drug loaded pharmacosomes and invasomes as vesicular carriers for enhancing transdermal permeation

Abstract

newlineIn recent research works, vesicular carrier drug delivery system reported a newlinevital role in enhancement of bioavailability and therapeutic response. Most newlinecommonly preferred vesicular carriers like, liposomes, ethosomes, nanosponges, newlinetransfersomes and lipid carriers like Solid Lipid Nanoparticles (SLN) posses major newlinedrawbacks like sedimentation, aggregation, preferring of too many solvents and low newlinedrug encapsulation and loading efficiency, drug leakage from vesicles during newlinestorage. In this research investigation, two novel carriers pharmacosomes and newlineinvasomes were selected as transdermal delivery systems, because of their newlinenumerous advantages like; both carriers posses bi-layered structural interactions, newlinecapability of encapsulating hydrophilic and lipophilic drugs, high encapsulation newlineefficiency and drug loading efficiency, preventing drug leakage from carrier during newlinestorage due to high binding affinity. Selection of drug plays a major role in case of newlinepharmacosomes ,only chemical structure of drug bearing (-COOH,-OH,-NH2) drugs newlineshould selected, drugs bearing an active hydrogen atom from this group can be newlineesterifies to the lipid with or without spacer chain leads to formation of amphiphilic newlinecompound which enhances the permeation towards the target site.