Pluronic polymer functionalized polymeric nanoparticles loaded capecitabine and thymoquinone for targeting colorectal cancer an experimental study

Abstract

Colorectal cancer (CRC), often known as colon cancer, typically originates as newlinea benign polyp in the colon or rectum and spreads slowly over 10 20 years. About newline9.4% of cancer-related deaths in 2020 were caused by CRC. Survival rates from CRC newlineare significantly affected by both recurrence and metastasis. In systemic therapy, the newlineproblem of non-targeted drug dispersion is of paramount importance. The main newlineworries and key grounds for chemotherapy failure are side effects and resistance to newlinemedicines, both of which are caused by this lack of specificity. To tackle these newlinechallenges, polymeric nanoparticles (PNP) were developed as transporter devices for newlineCRC therapy, with the ability to encapsulate diverse medications, shield therapeutic newlinemolecules, and give numerous advantages above their counterparts in bulk. To the newlineextent of our information this is the first work to demonstrate that functionalized newlinePolymeric nanoparticle loaded CAP and TQ can effectively be used as a synergistic newlinecombination to induce apoptosis, which could be used to kill off cancer cells. newlineAim newlineThis research aims to formulate a Nano-based drug delivery system targeting newlinecolorectal cancer. The objectives of the study are: newline1. To formulate, optimize, and evaluate pluronic polymer functionalized newlinenanocarrier system loaded Capecitabine and Thymoquinone. newline2. To assess the anticancer activity of optimized formulation by conducting in newlinevitro and in vivo studies. newline