Histochemical study of Mucopolysaccharides and microscopic Structure of osteoarthritic menisci Of the human knee joint

Abstract

Background: Osteoarthritis (OA) is a progressively disabling joint disease caused by newlinea pathological imbalance between degenerative and repair processes, for which there newlineis currently no cure. It is one of leading causes of chronic disability. Patients affected newlineby this disease experience pain and loss of function. OA can be caused by a variety of newlinefactors, including diet, injury, stress, and genetic abnormalities. However, the newlinemolecular mechanisms driving the disease onset and progression are not fully newlineunderstood. Knowledge regarding changes of mucopolysaccharides (proteoglycans) in newlinehuman osteoarthritis meniscus may help in understanding development of meniscal newlinedegeneration. Therefore, this study is undertaken to estimate a large number of human newlineOA menisci for study of mucopolysaccharides and microscopical structural changes newlinein osteoarthritic menisci by histochemical analysis of different parts of medial and newlinelateral menisci of both legs. newlineObjectives: newline1. To study the histochemistry of mucopolysaccharides in osteoarthritic menisci newlineof a Human knee joint. newline2. To study the microscopic structure of menisci in osteoarthritic patients. newline3. To compare the age-related changes in histological structure and newlinemucopolysaccharide changes in osteoarthritic menisci newline