Synthesis Biological Activity and Docking Studies of 1 and 3 and 4 Oxadiazole 2 Amine of 1 and 8 Naphthyridine Naphthalene and Benzene Derivatives

Abstract

ABSTRACT newlineThe work carried out during my research tenure has been collected in the form of a thesis newlineentitled SYNTHESIS, BIOLOGICAL ACTIVITY AND DOCKING STUDIES OF 1,3,4 newline-OXADIAZOLE-2-AMINE OF 1,8-NAPHTHYRIDINE, NAPHTHALENE AND newlineBENZENE DERIVATIVES is classified into five chapters. newlineChapter-I: An overview of 1,3,4-oxadiazole-2-amine and their derivatives newlineThis chapter describes the introduction, biological significance, synthesis of 1,3,4-oxadiazole newlinenucleus (brief-review), objectives and scope of the present research. newlineChapter-II: Synthesis, characterization and docking studies of new 5-(2-methyl 1,8- newlinenaphthyridin-3-yl)1,3,4-oxadiazol-2-amine and its derivatives of symmetrical newlineanhydrides newlineSynthesis of heterocyclic based on 1,8-naphthyridine and 1,3,4-oxadiazole scaffolds. This newlinechapter describes the synthesis and docking studies of new heterocyclic of 1,3,4-oxadiazoles2-amine and their derivatives with 1,8-naphthyridine as prime moiety. Chemical structures of newlineall the synthesized compounds were characterized on the basis of spectral data such as 1H and13CNMR, IR, mass and elemental analysis. newlineChapter-III: Synthesis, characterization and docking studies of 5-(naphthalen-5-yl)- newline1,3,4-oxadiazol-2-amine and its new derivatives of symmetrical anhydrides newlineSynthesis of 5-(naphthalen-5-yl)-1,3,4-oxadiazol-2-amine and its new derivatives of newlinesymmetrical anhydrides and their docking studies. This chapter deals the synthesis of 1,3,4- newlineoxadiazol-2-amine and its new derivatives with naphthalene moiety. Also describes the newlinedocking studies. Chemical structures of all the synthesized compounds were characterized on newlinethe basis of spectral data such as 1H and13C-NMR, IR, mass and elemental analysis. newlineChapter-IV: Synthesis, characterization and docking studies of new 1,3,4-oxadiazol-2- newlineamine of benzene derivatives newlinePART-A: Synthesis, characterization and docking studies of 5-(2-ethoxy phenyl)-1,3,4- newlineoxadiazol-2-amine and its new derivatives of symmetrical anhydrides newlineSynthesis of 5-(2-ethoxy phenyl)-1,3,4-oxadiazol-2-amine and its new derivatives of newlinesymmetrical anhydrides and also describes the docking studies. This chapter concern with the newlinesynthesis of new1,3,4-oxadiazol-2-aminederivatives with2-ethoxy phenyl and their docking newlineAbstract newlineMahatma Gandhi University 224 newlinestudies. Chemical structures of all the synthesized compounds were characterized on the newlinebasisof spectral data such as 1H and13C-NMR, IR, mass and elemental analysis. newlinePART- B: Synthesis, characterization and docking studies of 5-m-tolyl-1,3,4- newlineoxadiazol-2-amine and its new derivatives of symmetrical anhydrides newlineSynthesis of 5-m-tolyl-1,3,4-oxadiazol-2-amine and its new derivatives of symmetrical newlineAnhydrides and also describes the docking studies. This chapter deals with the synthesis newlineof new1,3,4-oxadiazol-2-aminederivatives with m-tolyl and their docking studies. newlineChemicalstructures of all the synthesized compounds were characterized on the basis of newlinespectral data such as 1H and13C-NMR, IR, mass and elemental analysis. newlineChapter-V: Biological screening, bactericidal and fungicidal activity of new newline1,3,4-oxadiazol-2-amine of 1,8-naphthyridine, naphthalene and benzene newlinederivatives newlineThis chapter states that all the synthesized compounds (Chapter-II, III, IVAand IVB) newlinewerescreened for their anti-bacterial and anti-fungal activity. newline