Effect of Mannan oligosaccharide MOS and medicinal plant supplementation on immune status of peri parturient goats and neonatal goat kids

Abstract

The present work was designed to study the following aspects of preweaning mortality in goat newlinekids. First one is influence of genetic and nongenetic factors on preweaning mortality of goat kids. newlineSecond one is to observe the effects of supplementing prebiotic and immunomodulatory polyherbal newlineformulation to pregnant goats on their immunity and metabolism, immune quality of their colostrum newlineand ultimately on immunity and growth of their kids. Lastly, effects of direct supplementation of these newlineformulations were observed on immunity, disease susceptibility and growth of neonatal goat kids. newlineEpidemiological study was conducted on three breeds maintained at CIRG Mathuraviz. Barbari, newlineJamunapari and Jakhrana whereas supplementation trial was conducted on pregnant Jamunapari goats newlineand neonatal kids. newlineOverall preweaning mortality rate of2.59 % was recorded in kids of all the three breeds. Kids newlinebirth weight, sex or age had no effect on mortality. Highest mortality was observed in kids born as newlinetriplet/quadruplet (4.49 %) followed by that in twins (2.88 %) and singlets (2.01 %). Dam s parity was newlinefound to have significant effect on mortality with highest mortality observed in kids born to newlineprimiparous dams (3.95 %) followed by kids born to dams having =/gt 5th parity (3.01 %) and least in newline2nd to 4th parity (1.82 %). newlineThe goats were supplemented 06 weeks prepartum to 04 weeks postpartum with yeast origin newlineprebiotic (MOS + ß-glucan) or polyherbal formulation (combination of crude powder of Withania newlinesomnifera roots, Tinospora cordifolia stem, Asparagus racemosus roots and Punica granatum fruit rind newlinein ratio of 3:3:3:1 by weight) at 100 mg/Kg body weight/day. Goats supplemented with polyherbal newlineformulation had significantly higher increase in serum IgG after 2 weeks of feeding. Both type of newlinesupplements induced more tolerogenic type of immune response in goats which was characterised by newlineless elaboration of IFN-and#947; compared to control animals in in vitro IGRA. Both supplements resulted in newlinesignificantly higher specific gravity of first drawn colostrum and kids born to prebiotic supplemented newlinegoats had higher plasma IgG post suckling and these kids. Kids born to prebiotic supplemented goats newlinewere more tolerant to LPS induced sepsis and natural infections during 1st month of life. No effect was newlineobserved on birth weight and growth rate of the kids. newlineIn another experiment, goat kids were directly fed daily from day 03 to day 30 of life with newlineextract of the polyherbal formulation or prebiotic. Supplementation with prebiotic or polyherbal newlineformulation resulted in significantly lower LPS induced release of cytokines - TNF-and#945; as well as IL-10 newlinecompared to unsupplemented goat kids and better resistance to infections during 1st month of life. newlineHowever, protective effect of the prebiotic on cumulative disease incidence lasted while it was being newlinefed regularly and then gradually waned off after the feeding was ceased. Here again, no positive effect newlinewas observed on growth rate of the kids. newline