Safety and Efficacy of Linga Chendhuram in the Clinical Management of Suram Pyrexia

Abstract

Fever (Pyrexia) is a symptom of elevation in body temperature associated in various disease conditions particularly in infectious and autoimmune diseases. Because of the hypothalamic thermoregulatory control normal body temperature is maintained instead of maintaining environmental temperature due to the excessive heat production derived from metabolic activity in liver and the muscle with heat dissipation from the lungs and skin. In Siddha literature, fever is considered as a disease under the terminology -Suram. Sage Theran denotes Suram is caused by an accumulation of aggravated Seetham in the alimentary tract which makes increase in body temperature. Suram is manifested as increased body temperature above its normal range, burning newlinesensation in eyes, pain in the body. nausea and vomiting. For treating pyrexia. Numerous medications were illustrated in the Siddha literatures. Among them, the herbometallic Sastric formulation Linga Chendhuram (LC) has been practiced frequently for treating fever, arthritis and venereal diseases. LC has been chosen for the study to prove as a safe and efficacious state of the drug in the management of fever in both animal model and human subjects. Linga Chendhuram (LC) was prepared in Gunapadam Laboratory of National Institute of Siddha, Chennai as per the method cited in the 1940 drug and cosmetic act authenticated literature Siddha Vaithiya Thirattu . Linga Chendhuram (LC) was analyzed for both qualitative and quantitative estimations. Preliminary physical parameters such as total ash, moisture content and extractive values were analyzed. The crystalline nature of Linga Chendhuram (LC) and main contents were analyzed using X-Ray diffraction study. The content of lead and cadmium were analyzed using Atomic Absorption Spectroscopic study. The concentration of elements in oxide form was analyzed through Wavelength dispersive X-Ray Fluorescence. The concentration of trace and heavy metals were analyzed using Inductively Coupled Plasma - Optical Emission Spectrometer.