Development and Characterization of Solid Dispersion Drug Delivery System

Abstract

The results of this study summarized as: Characterization of diacerein was done with melting point and FTIR spectroscopy study and found to comprise with the specification. The analytical method used was UV-spectroscopy for calibration curve of diacerein in DMA, SGF (pH 1.2), phosphate buffer 5.8, phosphate buffer 7.0 and HPLC for construction of calibration curve in plasma samples. Preformulation study of solid dispersion was done with solubility determination. Potential hydrophilic carrier s components were screened and selected as Soluplus®, PEG 6000. Solid dispersion by spray drying was done with lab scale spray dryer using PEG-6000 and Soluplus® as solid carriers at optimized conditions. Characterization of Diacerein solid dispersion was done with FTIR, XRD, DSC and SEM. Evaluation of solid dispersion was done for its physical appearance, spray drying process yield and powder flow properties. Optimization of solid dispersion was done on the basis of physical characterization, higher drug content, spray dried process yield and enhanced dissolution rate. The SD3 and SD6 batches were found to be optimized. newline Characterization of solid dispersion (Batches- PM3, PM6, FM3, FM6, SD3 and SD6) was done with differential scanning calorimetry (DSC) and powder XRD (PXRD); both the study reveals that decrease in the crystallinity of solid dispersion than that of pure drug. The present investigation has shown that it is possible to enhance the solubility and dissolution rate of diacerein thus improved bioavailability by solid dispersion with Soluplus® as solid carrier. The study was supported by all characterization parameter in desired way. Conclusions: It could be concluded that the use of novel polymer Soluplus® in solid dispersion formulations can enhance the solubility and dissolution rate of poorly water-soluble drug Diacerein significantly. At high Soluplus® content (1:4 or 1:8) the rate of dissolution enhancement was mostly dependent on the ratio of drug: carrier and the method of dispersion preparation.