Synthesis crystal structure biological activity and dna binding properties of transition metal complexes with schiff base ligands

Abstract

Transition metal complexes have huge applications in the vast areas from materials science to biological sciences. So chemists are very much interested to this field. Among the transition metal complexes, the metal complexes of Schiff bases are of greater interest. Schiff bases can be synthesized from an amine and a carbonyl compound by nucleophilic addition forming an imine. A wide number of studies had been carried out during the last decades on metal complexes of Schiff bases due to their synthetic flexibility, selectivity, sensitivity towards a variety of metal atoms and also due to various applications of these complexes in biology [1-12]. Schiff bases and their metal complexes are known to be biologically important and interesting because of their anti-inflammatory, anti-carcinogenic, antipyretic, anti-diabetic, anti-bacterial and antifungal properties [13, 14]. Besides, the interaction of Schiff base metal complexes with DNA has also gained much interest towards their applications as therapeutic agents. The scientific community has showed that metal coordination compounds have shown some interesting DNA-binding and cleavage properties, as well as antibacterial activities. Transition metals are particularly suitable for this purpose, because they can adopt a wide variety of oxidation states, coordination numbers and geometries, in comparison to other main group elements. So, over the past decades, considerable interest in the synthesis and characterization of transition metal complexes with Schiff Base ligands had been developed to examine the role of metal active sites in several catalytic biological processes. Significance of this type of complexes in bioinorganic chemistry gives further momentum to the extensive study of these complexes. newline