Comparative evaluation of the efficacy of Hydrocortisone suppository and Durvadi Gudavarti in Raktarsha

Abstract

Abstract: Background: Arsha, which is correlated to Hemorrhoids according to contemporary sciences, is a disease of yore. It is one of the most prevalent illnesses nowadays. It is the most common cause of bleeding per rectum in adults and the fourth leading diagnosis made in the gastrointestinal outpatient department. Aim and Objectives: This study aimed to compare the efficacy of Durvadi Gudavarti and Hydrocortisone acetate-based suppository in the management of Raktarsha (Bleeding Piles). Methods: A randomised active controlled double blind superiority clinical trial which involved 130 subjects between the age group of 20 to 60 years of Raktarsha, were assigned into two groups with equal allocation. The Control group (Group C) received Hydrocortisone suppository and Experimental group (Group E) received Durvadi Gudavarti for rectal administration twice daily (12 hourly) after proper evacuation of bowel, for a period 2 weeks. Clinical evaluations were performed at Baseline, 5th, 10th, 15th day post-inclusion. The main end point was proportion of subjects with complete clinical response and reduction in size of pile mass measured using transparent millimetre ruler on the 15th day. Results: Groups were homogeneous in terms of demographic and baseline characteristics. The Durvadi Gudavarti was found 34% and 32% more efficacious as compared to the Hydrocortisone acetate-based suppository in terms of reduction in size of pile mass and bleeding PR respectively. Interpretation and conclusions: Durvadi Gudavarti as rectal administration showed a significant advantage over a widely used standard treatment in the management of Raktarsha. Keywords: Raktarsha, Bleeding Piles, Durvadi Gudavarti, Haemorrhoids, Hydrocortisone suppository, Ayurvedic suppository. newline