Collagen chitosan based hydrogel formulation characterization and evaluation computational modeling of electroactive wound dressing

Abstract

The skin is the first line of defence against the invasion of diseases and newlineexternal objects and is the most significant organ in the human body. A newlinecutaneous wound is an injury to the skin that affects even the soft tissues newlinearound. These can either be excisional or incisional where the incisional newlinewounds are more prevalent and frequently include complex metabolic newlinealterations. Many underlying factors contribute to the failure of treatment of newlinesuch complicated wounds to move through a systematic and planned healing newlinestage. Therefore, it is difficult and unavoidable to restore anatomical structure newlineand function in the injured area. However, healing of these wounds is newlinenecessary in order to lessen the severe socio-economic burden created on the newlinesociety. newlineSuch complex wounds occur in the feet due to pressure (Pressure newlineulcers), accidental trauma to the feet, prolonged and unmanaged newlinehyperglycemic conditions (Diabetic Foot Ulcer). High exudate discharge, newlinenecrotic tissues, a lack of gaseous exchange, impaired wound healing due to a newlinelack of angiogenesis, abnormal toe brachial index, higher infection on site, newlinepoor inflammatory response, anatomical changes in the feet, variations in pH, newlineand temperature are just a few of the difficulties complex wounds present. newlineCurrently employed conventional treatment would not treat the complexities newlinein such wounds. Hence addressing these issues with novel strategies and newlineadjunct therapy is essential to provide a wholesome treatment newline