Analytical Method Development and Validations for the Determination of Impurities in the Aspirin Omeprazole Ofloxacin Levofloxacin and Agrochemical Flubendiamide by using Analytical Techniques

Abstract

The instrumental analysis involves not only in simple measurement itself, but also a newlinecomplex process including sampling, preparation of sample, and results evaluation. The newlineinstrumental analysis facilitates the analysis of large number samples in less time and minimum newlinesample usage. In this, the results achieved with very less sample volume in high-through screening newlinemethods and automation. Hence, this study focused to develop suitable analytical method for newlinesimultaneous analysis of selected drugs along with its impurities in formulations. One method newlinecomprises of HPLC quantitative method for simultaneous evaluation of aspirin and omeprazole in newlineformulations. Two analytical ICP-MS methods studied for quantifying 14 elemental impurities in newlineofloxacin and levofloxacin samples. One analytical HPLC method proposed for quantifying newlineveterinary drug Flubendiamide along with its process related impurities in technical grade newlineformulations. newlineFinally, it can be concluded that the methods represent in the thesis was confirmed as newlinesimple, precise, accurate and selective for the analysis of studied active pharmaceutical ingredients newlinealong with its impurities samples. The methods developed in the study were validated and all the newlinevalidation parameters were observed within the permissible limit. While applying the developed newlinemethod for the analysis of selected samples, it was proved that there is no interference of other newlinecompounds/ ingredients present in the samples while analyzing the selected compounds in the newlinemethod. Hence all these methods can useful for quantifying the studied active pharmaceutical ingredients along with its impurities and subsequently helpful for producing safe medicine. newline