Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/570995
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dc.date.accessioned2024-06-12T10:18:12Z-
dc.date.available2024-06-12T10:18:12Z-
dc.identifier.urihttp://hdl.handle.net/10603/570995-
dc.description.abstractThe thesis describes the general introduction about UV-spectroscopy, HPLC, HPTLC, herbal formulation, analytical method development, evaluation of different validation parameters and impurity profiling study. It highlights the background of the present research work. An exhaustive literature survey was conducted to identify the drug combinations for the development of simultaneous UV-spectroscopy, RP-HPLC, HPTLC methods. Based on the literature survey the combinations selected were: Cefixime (CEF) and Ofloxacin (OFL), Melatonin (MEL) and Zolpidem (ZOL), Tranexamic acid (TRA) and Mefenamic acid (MEF), Thiocolchicoside (THI) and Ketoprofen (KET), Citicoline (CIT) and Piracetam (PIR). The Aim and objectives of the proposed research work, which are as follows: 1. To select the FDA approved multi drug combinations, bulk drug and herbal formulation. 2. To develop quantitative techniques for the selected multi drug combinations by developing a new UV spectroscopic method, High Performance Liquid Chromatographic method and High Performance Thin Layer Chromatographic method. 3. To develop an impunity profiling method for the estimation of the bulk drug and its formulation. 4. To validate the above developed analytical methods as per ICH guidelines. Thus to conclude, in the present research work, UV spectroscopic, RP-HPLC and HPTLC methods were developed for selected drug combinations/herbal combination and an impurity profiling method was developed for a bulk drug. All the developed methods were validated as per ICH guidelines. The methods were simple, accurate, precise and robust. These methods can be successfully used for the determination of selected drug combinations and herbal formulation in pharmaceutical dosage forms and they can also be applied in routine quality control tests. RP-HPLC and HPTLC methods are more reliable and efficient. The UV spectroscopic method has an advantage that, It may be used in all routine quality control tests wherein use of sophisticated instruments is generally not feasible.
dc.format.extent295
dc.languageEnglish
dc.relation
dc.rightsuniversity
dc.titleDevelopment of New Analytical Procedure for Some Drug Formulation in New Combined Dosage Forms
dc.title.alternative
dc.creator.researcherVenkatachalam T
dc.subject.keywordCefixime (CEF)
dc.subject.keywordDevelopment
dc.subject.keywordDrug Formulation
dc.subject.keywordMefenamic acid (MEF)
dc.subject.keywordMelatonin (MEL)
dc.subject.keywordNew Analytical Procedure
dc.subject.keywordNew Combined Dosage Forms
dc.subject.keywordOfloxacin (OFL)
dc.subject.keywordTranexamic acid (TRA)
dc.subject.keywordZolpidem (ZOL)
dc.description.note
dc.contributor.guideLalitha K G
dc.publisher.placeChennai
dc.publisher.universityThe Tamil Nadu Dr. M.G.R. Medical University
dc.publisher.institutionDepartment of Pharmacy
dc.date.registered2010
dc.date.completed2014
dc.date.awarded2016
dc.format.dimensions
dc.format.accompanyingmaterialNone
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Pharmacy

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01_title.pdfAttached File116.69 kBAdobe PDFView/Open
02_prelim pages.pdf6.02 MBAdobe PDFView/Open
03_content.pdf263.28 kBAdobe PDFView/Open
05_chapter 1.pdf8.03 MBAdobe PDFView/Open
06_chapter 2.pdf4.71 MBAdobe PDFView/Open
07_chapter 3.pdf784.89 kBAdobe PDFView/Open
08_chapter 4.pdf1.4 MBAdobe PDFView/Open
09_chapter 5.pdf5.86 MBAdobe PDFView/Open
10_annexures.pdf15.5 MBAdobe PDFView/Open
10_chapter 6.pdf13.23 MBAdobe PDFView/Open
80_recommendation.pdf1.65 MBAdobe PDFView/Open


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