Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/568199
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dc.date.accessioned2024-05-31T06:16:23Z-
dc.date.available2024-05-31T06:16:23Z-
dc.identifier.urihttp://hdl.handle.net/10603/568199-
dc.description.abstractThe present study examined the feasibility of simultaneous delivery of Zolpidem tartrate and Zolmitriptan in the treatment of insomnia associated migraine through in situ nasal delivery system. 3 approaches were followed for the development of nasal in situ gels. They were thermoresponsive, pH responsive and dual acting. Preformulation study was performed through DSC and FT-IR spectral analysis of the drug and the polymers and it was found there was no interaction of the drugs in the presence of polymers. Initially, in situ nasal gels were developed separately for Zolpidem tartrate and Zolmitriptan i.e. thermoreversible nasal in situ gel of Zolmitriptan and pH responsive nasal in situ gel of Zolpidem tartrate. The pH responsive nasal in situ gel of Zolpidem tartrate included carbopol 934, HPMC K4M and sodium chloride in various ratios and these formulations were screened for viscosity, t80% drug release, pH, mucoadhesive strength and gel strength. The thermoreversible nasal in situ gel of Zolmitriptan included 3 polymers poloxamer 407, poloxamer 188 and PEG in various ratios. Gelation temperature was examined for Zolmitriptan gel. The formulations were coded as TISG-01 to TISG-08 and PISG-01 to PISG-08 and the results were compared. Based on the performance of the above findings another formulation, thermoreversible and pH responsive nasal in situ gel containing both Zolpidem tartrate and Zolmitriptan was developed with different ratios of poloxamer 407, carbopol 934, sorbitol, screened for the physicochemical and drug release characteristics as described above and the formulations were coded as DISG-01 to DISG-20. The physicochemical characteristics and the drug release profile of all the developed formulations were compared and it was found that all the formulations provided the results within the pharmaceutically acceptable limits. The results of the study demonstrates that a thermodynamic in situ nasal gel is beneficial for simultaneous delivery of Zolpidem tartrate and Zolmitriptan in the treatment of insomnia associated migraine effectively.
dc.format.extent276
dc.languageEnglish
dc.relation
dc.rightsuniversity
dc.titleNasal Drug Delivery of a Short Acting Hypnotic and Antimigraine Agent for the Treatment of Insomnia Associated Migraine
dc.title.alternative
dc.creator.researcherKarpagavalli L
dc.subject.keywordHypnotic and Antimigraine Agent
dc.subject.keywordInsomnia
dc.subject.keywordMigraine
dc.subject.keywordNasal Drug Delivery
dc.subject.keywordPharmacology and Pharmacy
dc.subject.keywordZolmitriptan
dc.subject.keywordZolpidem Tartrate
dc.description.note
dc.contributor.guideNarayanan N and Muthusamy P
dc.publisher.placeChennai
dc.publisher.universityThe Tamil Nadu Dr. M.G.R. Medical University
dc.publisher.institutionDepartment of Pharmacy
dc.date.registered2011
dc.date.completed2017
dc.date.awarded2021
dc.format.dimensions
dc.format.accompanyingmaterialNone
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Department of Pharmacy

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01_title.pdfAttached File112.28 kBAdobe PDFView/Open
02_prelim pages.pdf2.23 MBAdobe PDFView/Open
03_content.pdf297.16 kBAdobe PDFView/Open
05_chapter 1.pdf7.17 MBAdobe PDFView/Open
06_chapter 2.pdf365.3 kBAdobe PDFView/Open
07_chapter 3.pdf4.17 MBAdobe PDFView/Open
08_chapter 4.pdf320.31 kBAdobe PDFView/Open
09_chapter 5.pdf725.13 kBAdobe PDFView/Open
10_annexures.pdf5.54 MBAdobe PDFView/Open
10_chapter 6.pdf1.29 MBAdobe PDFView/Open
11_chapter 7.pdf360.46 kBAdobe PDFView/Open
12_chapter 8.pdf2.28 MBAdobe PDFView/Open
13_chapter 9.pdf8.56 MBAdobe PDFView/Open
14_chapter 10.pdf961.71 kBAdobe PDFView/Open
80_recommendation.pdf611.7 kBAdobe PDFView/Open


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