A study on Osteoarthritis of knee evaluating the effects of Biologics with Bio mechanical correction for Regeneration of Cartilage

Abstract

ABSTRACT newlineOsteoarthritis is the commonest condition of old population. It is characterised by restriction of movements and dull aching pain. It occurs due to destruction of joint cartilage. This leads to an increased friction of joint surfaces on one another which leads to pain, swelling, reduced movements and bony deformities. This condition affects any age group but most commonly involves older population. According to the Arthritis Foundation, prevalence of Osteoarthritis is 27 million people which is 3.8% of the population, more common in females and knee is the most common joint involved. Total knee replacement is the main surgical treatment in this condition but this procedure is difficult to perform, costly and may require repeated surgery.1,2 Although high tibial osteotomy is the treatment of choice in younger patients with isolated medial compartment disease but it has its pros and cons.3 newlineZhang et al. has reported that proximal fibular osteotomy is a useful surgery in knee osteoarthritis. It is easy to perform, inexpensive, has less complication rates, it has excellent functional outcome in terms of pain and this procedure may help to avoid Total knee replacement in selected patients.4 Lateral part of knee has support of proximal fibula so it has less tendency to collapse when compared to medial side. Proximal fibular osteotomy works by shifting the mechanical axis of the knee from medial to lateral joint and by decompression of the medial compartment.5 newlineWeight loss and exercise are excellent treatment options for OA, yet are often associated with poor compliance. There is a distinct need for new procedures that are cost effective by reducing the need for pharmaceutical and surgical management, while targeting the biochemical process of OA. Some of the experimental ortho-biological treatments include platelet-rich plasma (PRP) injection graft therapy, high-concentrate PRP (HcPRP), autologous bone marrow newlineaspirate concentration and adipose cells, IL-1 receptor antagonist, nerve growth factor inhibitor, and