A Study of Cardiac Morbidity in Diabetic and Hypothyroid Patients Undergoing Coronary Revascularization

Abstract

ABSTRACT newlineIntroduction newlineCAD is the primary cause of morbidity and mortality in developed and developing countries. DM and hypothyroidism are the most common endocrine disorders seen in adults, and their co-existence increases the risk of CAD. Complex, interdependent interactions characterize the association between T2DM and hypothyroidism, and their relationship is less explored in patients undergoing PCI. newlineAim and Objectives newlineThe aim of the study is to assess the clinical outcomes of PCI patients with T2DM and hypothyroidism. newlineMaterials and Methods newlineThe study is a single-centre prospective observational study. Consecutive patients and#8805; 18 years of age who underwent PCI between September 2020 and February 2022 at the Madras Medical Mission Hospital, Chennai, are included. The patients are categorized into 4 groups: Group I, euglycemic and euthyroid; Group II, T2DM and euthyroid; Group III, euglycemic and hypothyroid; and Group IV, T2DM and hypothyroid. The baseline investigations and clinical outcomes are assessed. Continuous and normally distributed data are presented as mean ± standard deviation. Non- normally distributed data are presented as medians with 25th and 75th percentiles. Categorical data are presented as frequency and percentages and the comparison between the two groups is done with a chi-square test. The comparison of means between the groups is tested using one-way ANOVA and the Kruskal-Wallis test based on distribution. The comparison of categorical variables between the two groups is done with a chi-square test. Statistical significance is set at a two-tailed p and#8804; 0.05. All statistical analysis are performed using SPSS version 25. newlineConclusion newlineThe current study showed that the presence of T2DM is the single most important predictor of outcomes and advances the understanding of the combined impact of T2DM and hypothyroidism in several ways. newline