Development of Phytoconstituents Enriched Formulations for Brain Health and its Pharmacokinetic and Pharmacodynamic Profile

Abstract

Herbal-based preparation progressively gaining popularity day by day. Major challenges associated with herbal preparations are about the lack of scientific evidence about pharmacodynamic and pharmacokinetic data, as well as information about their stability, solubility and bioavailability. A novel drug delivery approach to herbal preparation may newlinecombat the associated challenge. Crocus sativus is a popular herb used to improve and treat the memory and cognition related functions of the brain and thereby impose a significant role improving and maintaining brain health. The medicinal important part of Crocus sativus is a stigma of the flower which is rich in apocarotenoids, crocin, picrocrocin, safranal and many more volatile compounds. The pharmacological actions such as antioxidant, anti-amyloidogenic, anti-depressant, anti-depressant, anti cancer, antiinflammatory etc. properties are attributed due to of presence of carotenoids. newlineHowever the poor stability, solubility and enzymatic degradation of bioactives of Crocus sativus have substantially limited their therapeutic application. Crocin, a phytoconstituent present incrocus sativus extract is not absorbed from GIT. To overcome this challenge, it is encapsulated in the novel drug delivery system. The purpose of this study is to design and develop of nanoemulsion for Crocin enriched Crocus sativus extract and its pharmaceutical newlineevaluation along with its safety and in vivo efficacy. The reported average globule size and zeta potential were 94.89nm and-28.25 ± 1.256 mv. The TEM images had confirmed the uniform distribution of globules. Animals administered 500 mg/kg/day as single-dose of oral administration did not cause any signs of toxicity or mortality in rats and results of acute toxicity assessment of saffron nanoemulsion has indicated that the NOAEL (No Observed Adverse Effective Level) of saffron newlinenanoemulsion was found to be 500 mg/kg.