Establishment of effective anti cancer potential of betulinic acid nanoparticles

Abstract

Chemotherapy, which is commonly linked to major side effects, is the first line of defense against many cancer types. Plant extracts might possess anticancer qualities. Triterpenoids can alter a variety of signaling pathways in cancer cells, including Betulinic acid; however they are hydrophobic and have a low bioavailability. By specifically blocking oestrogen receptors, tamoxifen reduces the proliferation of cancer cells. However, it entails a significant and potentially fatal risk of blood clots, stroke, future endometrial cancer, and thromboembolic events. Formulations with drug-loaded nanoparticulate are the solution to the aforementioned problem. It has repeatedly been proposed that a mixture of lipids and polymers is the best substance for encasing a variety of drugs. newline