Shodhganga : a reservoir of Indian theses @ INFLIBNET
The Shodhganga@INFLIBNET Centre provides a platform for research students to deposit their Ph.D. theses and make it available to the entire scholarly community in open access.
Please use this identifier to cite or link to this item:
http://hdl.handle.net/10603/562867
| Title: | Cellular and molecular evaluation of aberrant hepatic DNA methylation by folate modulation and ageing |
| Researcher: | Najar, Rauf Ahmad |
| Guide(s): | Dar, Abid Hamid |
| Keywords: | Autophagy Cancer physiology Folate deficiency Folic acid Liver tissue folate levels Serum folate levels |
| University: | Panjab University |
| Completed Date: | 2017 |
| Abstract: | The present study was carried out in liver to elucidate the epigenetic, biochemical and molecular mechanism of folate modulation with ageing on folate transporters, and promoter methylation of tumor suppressor and proto-oncogenes in an in-vivo model of folate deficiency and supplementation, to understand the intricate mechanism between age and DNA methylation. The folate modulation was also observed in an invitro model of liver cancer cell lines to understand the role of mTOR associated with autophagy. newline |
| Pagination: | IV, 171p. |
| URI: | http://hdl.handle.net/10603/562867 |
| Appears in Departments: | Department of Biochemistry |
Files in This Item:
| File | Description | Size | Format | |
|---|---|---|---|---|
| 01_title.pdf | Attached File | 50.82 kB | Adobe PDF | View/Open |
| 02_prelim pages.pdf | 174.57 kB | Adobe PDF | View/Open | |
| 03_chapter1.pdf | 152.42 kB | Adobe PDF | View/Open | |
| 04_chapter2.pdf | 1.78 MB | Adobe PDF | View/Open | |
| 05_chapter3.pdf | 390.76 kB | Adobe PDF | View/Open | |
| 06_chaoter4.pdf | 3.69 MB | Adobe PDF | View/Open | |
| 07_chapter5.pdf | 906.11 kB | Adobe PDF | View/Open | |
| 08_chapter6.pdf | 159.28 kB | Adobe PDF | View/Open | |
| 09_annexure.pdf | 464.18 kB | Adobe PDF | View/Open | |
| 80_recommendation.pdf | 199.58 kB | Adobe PDF | View/Open |
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