Design and Development of Oral Osmotic Controlled Drug Delivery System for Anti Hypertensive Drugs

Abstract

Numerous drug delivery systems have been developed by many researchers to modulate and release a drug over an extended period of time. Among them osmotic drug delivery system plays an important role in controlling the drug release in a constant manner for prolong period of time. A survey of the literature indicated that extensive work was conducted in the development and fabrication of different types of osmotic drug delivery system for pharmaceutically active materials such as Nifedipine, Captopril, Ketoprofen, Indomethacin, Oxybutynin, Theophylline, Ciprofloxacin, etc. Among them, most of the work had carried out in anthihypertensive drugs since they need control over a long period of time in order to increase the therapeutic efficacy, reduced the resistance developed by monotherapy, lower the systemic side effects, decreased the frequency of administration, and thereby improved the patient compliance and adherence to the therapy. Metoprolol succinate and Ramipril were one among the combinations wildly used in the treatment of mild to moderate hypertension, angina pectoris, congestive heart failure, etc., and also beneficial in post-infarction patients. This combination of drugs is currently available in commercial market as film coated, SR, ER tablets, but they lack in providing constant release for a period of 24 hrs. Thus in this study, an attempt was made to utilize osmotic principle for developing three types of osmotically controlled release dosage form of Metoprolol succinate and Ramipril namely CPOP, SCPOP and SEOP with an aim to deliver the drugs as solution for prolonged period of time in a controlled manner. ODDS technology has also enabled the use of an effective starting dose, without the need for dose titration, which allows the achievement of symptom control much earlier than that observed with immediate-release preparations. On the basis of results obtained it was concluded that this system is simple to prepare and can be used in the field of controlled drug delivery of drugs. newline