Study of antifungal drug susceptibility of dermatophytes virulence factors immunological response with the severity of the infection

Abstract

Dermatophytes are common fungal pathogens responsible for dermatophytosis or ringworm in humans This study aims to comprehensively investigate various aspects of dermatophyte infections including antifungal susceptibility virulence factors immunological responses and their potential associations with infection severity Collection of clinical isolates Dermatophyte isolates were obtained from patients with varying degrees of dermatophytosis severity Antifungal susceptibility testing Standardized methods were employed to assess the susceptibility of dermatophytes to commonly prescribed antifungal drugs Virulence factor characterization Virulence factors such as proteases keratinases and adhesion molecules were analyzed to understand the mechanisms of fungal pathogenicity Immunological assessment Cytokine profiles were measured in dermatophytosis patients to evaluate host immune responses In our two-year study Jan 2016 Oct 2018 250 samples were collected primarily from females 51point 6 percent The most susceptible age group was 30 to 40 years Chronic dermatophytosis affected 64 percent with T mentagrophytes and T rubrum isolates showing varying biofilm forming abilities Antifungal susceptibility patterns indicated rising resistance trends notably with terbinafine and griseofulvin Enzymatic activity was significant and MBL levels correlated with infection type Total serum IgE levels associated with illness length and body surface area involvement Dermatophytes formed biofilms complicating treatment newlineThis multidisciplinary investigation into dermatophyte infections provides a comprehensive understanding of their susceptibility to antifungal drugs virulence factors immunological responses and their interplay with infection severity The findings have implications for improving treatment strategies and advancing our knowledge of dermatophyte infections newline newline newline