A study on Ghrelin in hypertensives

Abstract

Hypertension is a global health concern leading to disability reduced quality of life and economic burden In the context of cardiovascular health ghrelin a hormone primarily produced by the stomach has gathered attention Ghrelin plays a multifaceted role in the regulation of blood pressure and endothelial function HRV assessment aids in evaluating the autonomic regulation of the heart Reactive oxygen species play a role in the development of hypertension contributing to oxidative stress and cardiovascular dysfunction Hence this study was conducted to compare the levels of ghrelin in hype tensives and normotensives which may help to identify underlying mechanisms that contribute to the development of hypertension Material and 160 study participants were selected based on the selection criteria and were divided into group 1 healthy volunteers group 2 and 3 hypertensive subjects according to the severity of hypertension Informed written consent was obtained and the study questionnaire was administered Ghrelin levels were measured using the sandwich ELISA technique Total antioxidant activity was measured by the FRAP assay Accelerated pulse wave plethysmography was obtained using the APPG module Heart Rate Variability was recorded using analogue device model no AD8232 Statistical analysis was carried out using R software Significant reduction in Ghrelin levels TAO status and vascular compliance parameter with an increase in blood pressure was observed Time domain HRV parameters like SDNN RMSSD and NN50 were significantly increased with an increase in blood pressure Significant negative correlation was observed between Ghrelin vs Blood pressure and a positive correlation between Ghrelin levels and TAO status a positive correlation between Ghrelin and vascular compliance None of the confounding variables had a significant impact on Ghrelin levels in hypertensives This is the first Indian study reporting that there is a reduction in plasma ghrelin levels in hypertensives Ghrelin levels are inversely correlated wit