A Comparison of Prevalence of Subclinical Hypothyroidism in Urban and Rural Population

Abstract

i newlineABSTRACT newlineIntroduction-Subclinical hypothyroidism can be defined as high serum TSH newlineconcentration with normal Free Thyroxine (FT4) and Free Triiodothyronine (FT3) newlineconcentration, associated with few or no signs and symptoms of hypothyroidism. It newlineis the most prevalent thyroid disorder affecting 3-15% of the adult population. newlineSubclinical hypothyroidism has been reported to have prevalence of about 4-10% in newlinethe general population and 7-26% in the geriatric population. The prevalence of newlinesubclinical hypothyroidism is about 4 to 8.5% in females aged more than 60 yrs. [9] newlineAfter a thorough literature search, it was found that prevalence of subclinical newlinehypothyroidism in the general population of India has not been reported. Therefore, newlinethis study was planned to find out the prevalence of subclinical hypothyroidism in newlineIndia and to compare the prevalence in urban and rural populations. newlineResearch questions: newline1. Does the prevalence of subclinical hypothyroidism differ in urban and rural newlinepopulation? newline2. Does the prevalence of coronary risk factors differ in urban and rural patients newlinewith subclinical hypothyroidism? newlineStudy area and population: The study will be conducted on 400 subjects from newlinerural areas (area comes under Gram panchayat) and 400 subjects from urban areas newline(area comes under Municipal Corporation or Municipal Committee) of Amber Tehsil newlinein Jaipur District. The study will be conducted in National Institute of Medical newlineSciences and Research, Jaipur. newlineResearch centre: Department of Biochemistry, National Institute of Medical science and newlineResearch centre (NIMS) super specialty hospital, Jaipur (Raj) newlineInclusion criteria: newlineand#61623; Adult subjects from urban and rural population. newlineand#61623; Method of Randomization- Simple randomization method will be used for newlinethe selection of subjects. Every fiftieth house will be selected for this study newlineii newlinein defined area. If total houses in any village are less than 50, then randomly newlineany one house will be selected. newlineand#61623; Those willing to participate in the study newlineExclusion criteria: newlineand#61623; Pregnant women.