Cardiovascular autonomic function tests in type II diabetics and non diabetics

Abstract

quot ABSTRACT newlineIntroduction: Current study, intended to evaluate the type and degree of cardiovascular newlineautonomic activity using heart rate and blood pressure variations from supine to newlinestanding, isometric hand grip exercise, cold pressor test, and their association with newlineglycated hemoglobin levels and its plausible link to the cardiovascular dysfunctions in newlinepatients with type 2 diabetes and non-diabetics. newline newlineMaterials and Methods: In this case-control comparative study, a total of 455 with the newlineage group of 35-60 years old, type-II diabetic patients and 455 of age and gender newlinematched normal healthy individuals were recruited as control subjects. newline newlineResults: on immediate standing there was significant (P=0.0325) difference in SBP, newlineHeart rate significantly (Plt0.0001) less, DBP significantly (Plt0.0001) high between newlinethe control and study group. Effect of heart rate and blood pressure variations on cold newlinepressor test was heart rate 9.18% less and, SBP 17.86% and DBP 17.43% more in study newlinegroup compared to controls. In isometric hand grip exercise test between study group newlineand control subjects heart rate significantly (Plt0.0001) decreased, the SBP and DBP newlinewere significantly (Plt0.0001) high. newline newlineDiscussion: In the present study, type-II diabetic patients had significant increase in newlineDBP and decreased heart rate compared to their age-matched controls. The presence of newlinedisorders like coronary artery disease, heart failure, diabetes, and hypertension are newlinetypically indicated by a reduced heart rate. Type-II diabetics showed increased newlinesympathetic activity to cold pressor test, increased sympathetic reactivity to handgrip newlinetest.quot newline newline