Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/544807
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dc.date.accessioned2024-02-09T12:18:38Z-
dc.date.available2024-02-09T12:18:38Z-
dc.identifier.urihttp://hdl.handle.net/10603/544807-
dc.description.abstractA total of 1539 bovine milk samples were collected from six districts of North Eastern Tamil Nadu and Chennai. Based on the TANUCHECK SCC kit, subclinical and clinical mastitis positive milk together was 1086. From a total of 438 Staphylococcus spp isolated, 90 were coa+ve and 348 were coa-ve. A total of 260 Escherichia coli isolates were obtained from bovine mastitis milk. newlineBoth the Staphylococcus spp and Escherichia coli isolates were subjected to cultural and bio-chemical characterization. By the antibiotic sensitivity test, the phenotypic sensitivity / resistance pattern was recorded for 15 different antibiotics falling under five different drug class. newlineThe AST efficacy for drug conjugated Chitosan NPs was highest for Chitosan+Ampicillin (CHT+AMP)100% followed by Chitosan+Erythromycin (CHT+E) -75% and Tetracycline (CHT+TE) (38.88%) and (CHT+GEN) Gentamicin having (10.52%) lower action against the resistant E. coli isolates. newlineIrrespective of the resistant isolate used, the efficacy of antibiotics after conjugation with Chitosan was highest for Tetracycline (92.30%); followed by Ampicillin (66.66%); Erythromycin (46.15%) and Cefotaxime (40%). newlineIn comparison to both the nano particles, the antibiotic conjugated Chitosan NPs exhibited synergistic and higher antibacterial effect against the resistant isolates of both Staphylococcus spp and E. coli. The ZnO NPs conjugated antibiotics had lower efficacy towards the resistant bacterial isolates. newlineKey words: Bovine mastitis, Staphylococcus spp., Escherichia coli, abr genes, resisitant antibiotics, nano particles, ZnO NPs, Chitosan NPs. newline newline
dc.format.extent264
dc.languageEnglish
dc.relation
dc.rightsuniversity
dc.titleNano antibiotics as an alternative therapy for drug resistant bacterial pathogens causing bovine mastitis
dc.title.alternative
dc.creator.researcherLatha Mala Priyadharshini, M
dc.subject.keywordAgricultural Sciences
dc.subject.keywordAgriculture Dairy and Animal Science
dc.subject.keywordLife Sciences
dc.description.note
dc.contributor.guideManoharan, S
dc.publisher.placeChennai
dc.publisher.universityTamil Nadu Veterinary and Animal Sciences University
dc.publisher.institutionVeterinary Microbiology-MVC
dc.date.registered2018
dc.date.completed2022
dc.date.awarded2023
dc.format.dimensionsA4
dc.format.accompanyingmaterialDVD
dc.source.universityUniversity
dc.type.degreePh.D.
Appears in Departments:Veterinary Microbiology-MVC

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01_title.pdfAttached File86.85 kBAdobe PDFView/Open
02_prelim pages.pdf531.07 kBAdobe PDFView/Open
03_content.pdf239.31 kBAdobe PDFView/Open
04_abstract.pdf210.85 kBAdobe PDFView/Open
05_chapter 1.pdf112.55 kBAdobe PDFView/Open
06_chapter 2.pdf1.74 MBAdobe PDFView/Open
07_chapter 3.pdf472.38 kBAdobe PDFView/Open
08_chapter 4.pdf4.51 MBAdobe PDFView/Open
09_chapter 5.pdf189.53 kBAdobe PDFView/Open
10_annexures.pdf289.42 kBAdobe PDFView/Open
80_recommendation.pdf201.1 kBAdobe PDFView/Open


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