Preparation and Characterization of Noble Ocular Formulations for the Treatment Of Dry Eye

Abstract

Dry eye is a chronic tear film imbalance linked to ocular dyshomeostasis causing newlineinflammatory damage and neurosensory loss. The prevalence was determined to be newlinebetween 5 and 50% and the risk increased with age. An increase in infections and newlineinflammation in dry eye patients indicates there is an opportunity to improve the newlineeffectiveness of diagnostic and current treatment methods. Currently, ophthalmic drops newlinewith hydrophilic polymers and symptomatic drugs are frequently employed for the newlinetreatment of dry eye syndrome. However, excess lacrimation, nasolacrimal clearance, newlinelow cul-de-sac volume, corneal epithelial barrier, and poor retention time are the main newlineobstacles that call for multiple administrations. The frequent and prolonged use of eye newlinedrops containing preservatives can lead to ocular irritation, which can lead to eye pain newlineand tear film instability, exacerbating the dry eye problem. Irrespective of difficulties, newlinesuch as heterogeneous corneal barriers, tear drainage systems, and blood-aqueous newlinebarriers, topical drop instillation remains the most accessible route of drug newlineadministration to treat dry eye syndrome. newlineMucoadhesive drug delivery systems with the ability to customize drug release newlineprofiles might be a good option for enhancing the effectiveness of the ocular newlineformulation. Over the years a variety of mucoadhesive drug delivery systems, such as newlinesitu gelling systems, polymeric nanoparticles, liposomes, lipid-based nanocarriers, nano newlineemulsions, etc. have been thoroughly investigated for the management of dry eye newlinesyndrome. However, the presence of a lot of surfactants, preservatives, poor drug newlineloading, immature drug release, and poor stability, continue to be some of the newlinefundamental issues that restrict the therapeutic potential of novel drug delivery systems. newlinePolymeric carrier systems continue to be the preferred option among many carriers newlinebecause of their controlled drug release capability, biodegradability, good mucoadhesive newlinequalities, and tailored physiochemical features. Physical instability, drug release,