HER2NEU PDL1 and KI67 and their correlation with clinicopathological parameters in gastric adenocarcinoma

Abstract

Introduction: newlineGastric adenocarcinoma world. The usually in the advanced stage metastasis purpose of this is to evaluate Ki-67 index, which is the rate of proliferation of the tumor, Her2neu, which is responsible for the rapid increase and survival tumor, which is charge central immune tolerance. newlineAims and objectives: newlineand#61623; To determine the value of each marker as a single prognostic indicator. newlineand#61623; To establish correlation between these markers, clinicopathological parameters and clinical outcome. newlineMaterials and methods: newlineWe obtained 42 cases of gastric adenocarcinoma from archival blocks since 2018 and included newly diagnosed cases until February 2022. Hematoxylin and eosin slides were assessed to determine the grade of tumor. Immunohistochemistry of Her2neu, based on protocol manual provided by the institute. Appropriate control slides were used along with the tumor tissue, following which, scoring of the IHC slides was done. Clinical details and survival status of the patients was collected. newlineResults: newlineThe most common age group affected was the older age group, with a male preponderance and most of them were grade 3 tumors. distant metastasis and mortality status. All three markers were associated with a poor prognosis. newlineConclusion: newlineIn order to minimize mortality due to gastric carcinoma, combined targeted therapy with anti-Her2neu and anti-PD-L1 in carcinomas that express these markers can be considered to improve the over-all survival of the patient. newline