Compression Coating Technology Employing Modified Gums for Developing Gastro retentive Tablets of Cinnarizine

Abstract

The study has been classified into two stages: firstly, carboxymethylation of the guar gum, locust bean gum, and karaya gum, and second the development and evaluation of formulation of cinnarizine by compression coating technology. Also, there is a comparison study between pure gum-based formulation and carboxymethylated formulation. newlineCarboxymethylation reaction was performed on the guar gum (GG) and it s characterized by SEM, XRD, and FTIR techniques. The SEM morphology changes after carboxymethylation of guar gum depicts surface roughness with relatively irregular edges. The XRD confirms after the carboxymethylation of the guar gum reduction in the crystalline behavior. The inner core tablets of cinnarizine were developed by using Magnesium stearate, Polyvinyl pyrrolidine (K30), and Microcrystalline cellulose. The evaluation parameters result like, the weight of inner core tablets of cinnarizine was 80±5 mg. Hardness and friability were 3.0±0.50 kg/cm2 and 0.80±0.17 % respectively. The thickness of the core tablets was 1.75 ±0.10 mm. After the inner core evaluation, the outer core of the tablet was developed by using Carboxymethylated guar gum, MCC, PVP, and Talc through compression coating technology. Tablet weights are between 601.2 ±2.04 mg to 608.3±2.70 mg. The hardness of tablets is 5.1±0.10 kg/cm2 to 6.9±0.45 kg/cm2 differing significantly in polymer properties and strength. Friabilator results are to be correlated with the hardness of guar gum (GG) and carboxymethylated guar gum (CGG) was below 1% upper acceptable limit. The mucoadhesive test is based on the detachment force (N) between the tablet and the mucus membrane. Detachment force was between 4.32±0.89 to 18.53±2.08 N. Carboxymethylated guar gum depicts sustained release behavior in the compression-coated tablets of cinnarizine on in-vitro drug release. In conclusion, carboxymethylated guar gum is a suitable polymer candidate for developing a mucoadhesive drug delivery system with a controlled release property. newline