Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/539613
Title: Formulation Characterization and Optimization of Nanostructured Lipid Carriers for Topical Delivery of Fenoprofen Calcium
Researcher: Ishrat Zahoor
Guide(s): Rajni Bala and Sukhbir Singh and Neelam
Keywords: Clinical Pre Clinical and Health
Pharmacology and Pharmacy
Pharmacology and Toxicology
University: Chitkara University, Punjab
Completed Date: 2023
Abstract: Fenoprofen calcium is a nonsteroidal anti-inflammatory drug used to alleviate pain, osteoarthritis and rheumatoid arthritis-related discomfort, inflammation, and stiffness. Due to the possibility of serious gastrointestinal side effects like ulceration, irritation, and gastric bleeding, its oral administration is often restricted. It has a short elimination half-life of approximately 3 hours and therefore, regular doses are required to maintain an anti-inflammatory/analgesic effect. But the frequent doses which were necessary for exerting a continuous effect, further causes severe gastrointestinal adverse effects. So, the development of alternative methods which enhances the duration of their plasma half-life, reduces the dosing frequency and side effects by targeting the drugs to the site of action as well as provides the better patient compliance are required. So, there is a need of utilization of novel drug delivery system (NDDS) for the Fenoprofen calcium drug molecules in order to target the site-specific region, to achieve desired therapeutic effect, thereby reducing the side or toxic effects for having better acceptance and compliance, this approach provided an option for the utilization of nanostructured lipid carriers (NLCs) for encapsulation of Fenoprofen calcium and then incorporation these Fenoprofen calcium loaded NLCs into topical gel which could be beneficial in preventing oral side effects and maximizing anti-inflammatory/analgesic activity to inflamed skin and increasing patient compliance. NLCs generally varies in size from around 10 to 1000 nm. NLC may exist in the form of a solid matrix made of lipids both at room and the body temperature. When applied topically, lipids generate a film with occlusive properties that help keep moisture in the skin for longer. The topical drug delivery of Fenoprofen calcium is one of the strategies that might be used to avoid the issues that are connected with its oral route of administration. The administration of the medication to the topical surfaces circumve
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URI: http://hdl.handle.net/10603/539613
Appears in Departments:Faculty of Pharmacy

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01_title.pdfAttached File10.19 kBAdobe PDFView/Open
02_prelim pages.pdf408.33 kBAdobe PDFView/Open
03_content.pdf326.92 kBAdobe PDFView/Open
04_abstract.pdf163.53 kBAdobe PDFView/Open
05_chapter 1.pdf1.87 MBAdobe PDFView/Open
06_chapter 2.pdf444.32 kBAdobe PDFView/Open
07_chapter 3.pdf734.64 kBAdobe PDFView/Open
08_chapter 4.pdf3.32 MBAdobe PDFView/Open
09_chapter 5.pdf438.55 kBAdobe PDFView/Open
10_annexures.pdf763.08 kBAdobe PDFView/Open
80_recommendation.pdf379.75 kBAdobe PDFView/Open
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