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http://hdl.handle.net/10603/539613
Title: | Formulation Characterization and Optimization of Nanostructured Lipid Carriers for Topical Delivery of Fenoprofen Calcium |
Researcher: | Ishrat Zahoor |
Guide(s): | Rajni Bala and Sukhbir Singh and Neelam |
Keywords: | Clinical Pre Clinical and Health Pharmacology and Pharmacy Pharmacology and Toxicology |
University: | Chitkara University, Punjab |
Completed Date: | 2023 |
Abstract: | Fenoprofen calcium is a nonsteroidal anti-inflammatory drug used to alleviate pain, osteoarthritis and rheumatoid arthritis-related discomfort, inflammation, and stiffness. Due to the possibility of serious gastrointestinal side effects like ulceration, irritation, and gastric bleeding, its oral administration is often restricted. It has a short elimination half-life of approximately 3 hours and therefore, regular doses are required to maintain an anti-inflammatory/analgesic effect. But the frequent doses which were necessary for exerting a continuous effect, further causes severe gastrointestinal adverse effects. So, the development of alternative methods which enhances the duration of their plasma half-life, reduces the dosing frequency and side effects by targeting the drugs to the site of action as well as provides the better patient compliance are required. So, there is a need of utilization of novel drug delivery system (NDDS) for the Fenoprofen calcium drug molecules in order to target the site-specific region, to achieve desired therapeutic effect, thereby reducing the side or toxic effects for having better acceptance and compliance, this approach provided an option for the utilization of nanostructured lipid carriers (NLCs) for encapsulation of Fenoprofen calcium and then incorporation these Fenoprofen calcium loaded NLCs into topical gel which could be beneficial in preventing oral side effects and maximizing anti-inflammatory/analgesic activity to inflamed skin and increasing patient compliance. NLCs generally varies in size from around 10 to 1000 nm. NLC may exist in the form of a solid matrix made of lipids both at room and the body temperature. When applied topically, lipids generate a film with occlusive properties that help keep moisture in the skin for longer. The topical drug delivery of Fenoprofen calcium is one of the strategies that might be used to avoid the issues that are connected with its oral route of administration. The administration of the medication to the topical surfaces circumve |
Pagination: | |
URI: | http://hdl.handle.net/10603/539613 |
Appears in Departments: | Faculty of Pharmacy |
Files in This Item:
File | Description | Size | Format | |
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01_title.pdf | Attached File | 10.19 kB | Adobe PDF | View/Open |
02_prelim pages.pdf | 408.33 kB | Adobe PDF | View/Open | |
03_content.pdf | 326.92 kB | Adobe PDF | View/Open | |
04_abstract.pdf | 163.53 kB | Adobe PDF | View/Open | |
05_chapter 1.pdf | 1.87 MB | Adobe PDF | View/Open | |
06_chapter 2.pdf | 444.32 kB | Adobe PDF | View/Open | |
07_chapter 3.pdf | 734.64 kB | Adobe PDF | View/Open | |
08_chapter 4.pdf | 3.32 MB | Adobe PDF | View/Open | |
09_chapter 5.pdf | 438.55 kB | Adobe PDF | View/Open | |
10_annexures.pdf | 763.08 kB | Adobe PDF | View/Open | |
80_recommendation.pdf | 379.75 kB | Adobe PDF | View/Open |
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