Correlation of lipid profile with echocardiographic changes related to left ventricular dysfunction in patients with chronic kidney disease

Abstract

Background: At each and every stage of CKD, CVDs are the major reason of mortality and morbidity in subjects. Depending on the level of CKD, individuals with CKD have a significantly elevated risk of developing cardiovascular diseases comparable to age and sex-matched individuals in the wider community. Dyslipidaemia is a significant traditional predisposition for CVD in persons with ESRD. Managing these hazards may considerably reduce the added stress of CHD. This research was done to evaluate the echocardiographic results and lipid profile of individuals having CKD. newlineMethods: An observational study was carried out on individuals who are CKD in the General Medicine department of Chettinad Medical College Hospital and Research Institute from February 2022 to September 2022. This research comprised a total of one hundred individuals with CKD. This research gained ethical permission from the IEC to evaluate the changes in lipid profile and echocardiographic findings in patients with CKD. Relevant data was collected from all subjects and analysed using SPSS. newlineResults: In the present study LVH was reported in 28% of subjects, calcifications were noted in 23% of subjects, PE in 5% of subjects and CCF in 6% of subjects. Mean LVID, IVS, PDW, LVMI were significantly increases with severity of CKD. Also, association between presence of LVH and severity of CKD was remarkable. On assessing lipid levels, increasing levels of TC, TG, LDL and VLDL were noted with respect to increasing severity of CKD and also decreasing levels of HDL was noted with increasing severity of CKD. Also, the association between dyslipidemia and severity of CKD was clearly established. newlineConclusion: We infer than all the subjects with CKD should undergo periodic Echo evaluation for the assessment of cardiac abnormalities along with periodic assessment of lipid profile in order to prevent adverse complications. newlineKey words: Echo findings, CKD, lipid profile, LVH newline