Study of Protein Kinase Inhibitors by QSAR Modeling and Molecular Docking

Abstract

The general introduction of protein kinase inhibitors is covered in Chapter I. This also includes newlineinformation on five specific protein kinase inhibitors (PLK1, RIPK2, CK1 delta, ATM, and newlineLRRK2). There were descriptions of all the different descriptors utilised in the QSAR newlineinvestigation. A quick introduction to the computational method, QSAR modeling, and docking newlinestudy was also mentioned. newlineChapter II is focused on the literature review of the developed QSAR models for different newlineprotein kinase inhibitors. The literature evaluation of previously investigated protein kinase newlineinhibitors from the years 2005 to 2023 was taken into consideration. Numerous QSAR newlineinvestigations have been carried out on several protein kinase inhibitors, including p56lck, newlineGSK-3, EGFR, JNK, and many more, according to the literature review, however, no QSAR newlinemodel has been discovered so far for the chosen protein kinase inhibitors. Therefore, these newlineinhibitors were chosen. newline newline