A study on the association of lipid profiles with severity and outcome of acute ischemic and haemorrhagic stroke in patients in a tertiary care hospital

Abstract

BACKGROUND: newlineStudies conducted for the distinction between IS and HS have revealed newlinepositive association and also negative association between different lipid profile newlineparameters. Therefore, this study was conducted to examine the lipid status of IS and HS newlineparticipants and the relationship between them. newlineMETHODS: newlineA cross sectional study was conducted in Department of General Medicine, newlineChettinad Medical College Hospital and Research Institute among patients admitted with newlineAIS and HS during April 2021 to April 2022. A total of hundred in each IS and HS with a newlinetotal of 200 stroke subjects were included. Ethical committee approval was obtained for newlinethis study from the IHEC of our Institute. newlineRESULTS: newlineIS and HS subjects were similar in age, BMI, smoking habit, alcohol newlineconsumption, family h/o stroke, hemiplegia, paraplegia, facial nerve involvement, NIHSS newlinescores, MRS scores, and GCS scores. Notably, TC, TLG and HDL amounts were newlinesignificantly high in IS compared to HS. However, LDL and VLDL did not remarkably newlinediffer between the two groups. Also, we found a categorical association between TC, TLG newlineand HDL with the IS and HS whereas LDL and VLDL did not show any significant newlineassociation with type of strokes. newlineDuring follow up assessment, MRS and GCS were improved and on newlineassessing the lipid profile, HDL still remains remarkably high in IS group compared to HS newlinegroup however, TC, TLG, LDL and VLDL were similar in both the groups. newlineCONCLUSION: newlineWe infer that TC, TLG and HDL were remarkably high in IS compared to newlineHS. Hence we suggest to suspect dyslipidemia in IS cases even before doing investigation newlineand vice versa. newlineKEY WORDS: newlineDyslipidemia, IS- Ischemic stroke, HS- hemorrhagic stroke, association newline TC Total Cholesterol, TLG Triglycerides, VLDL Very Low Density newlineLipoprotein newline HDL - High-density lipoprotein newline