Please use this identifier to cite or link to this item: http://hdl.handle.net/10603/528409
Title: Exploring ribosome mediated translation regulation in mammals
Researcher: Hariharan, Nivedita
Guide(s): Palakodeti, Dasaradhi
Keywords: ES30L
expansion segments
Life Sciences
Plant and Animal Science
ribosome
rRNA
Zoology
University: Institute of Trans-disciplinary Health Science and Technology
Completed Date: 2023
Abstract: Mammalian ribosomes have nearly doubled in size compared to the bacterial ribosomes. This is attributable, in part, to the presence of multi-nucleotide insertions in the ribosomal RNA (rRNA) called Expansion Segments (ESs). Even though ESs were first identified at least four decades ago, we still do not possess any understanding of the variability or function of most of these segments across eukaryotes. Given that ribosomes have been gaining prominence for their potential to actively regulate translation, understanding ESs in this context would be very beneficial. newline newlineHence, we investigated the variability of the large subunit ESs across eukaryotes, which included the presence of species-specific expansions. Further, from our study, we observed that one such expansion called ES30L, was present only in endothermic vertebrates (birds and mammals). This expansion appears as a highly flexible extension from the L1-stalk, which is located on the side of tRNA and mRNA exit sites. Using a combination of computational and experimental approaches, this work highlights aspects by which ES30L can interact with protein-coding transcripts and also proteins that are involved in translation. newline newline
Pagination: 
URI: http://hdl.handle.net/10603/528409
Appears in Departments:Centre for Functional Genomics & Bio-informatics

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02_prelimpages.pdf526.55 kBAdobe PDFView/Open
03_content.pdf109.61 kBAdobe PDFView/Open
04_abstract.pdf29.87 kBAdobe PDFView/Open
05_chapter1.pdf5.01 MBAdobe PDFView/Open
06_chapter2.pdf203.5 kBAdobe PDFView/Open
07_chapter3.pdf8.85 MBAdobe PDFView/Open
08_chapter4.pdf3.6 MBAdobe PDFView/Open
09_chapter5.pdf4.33 MBAdobe PDFView/Open
10_chapter6.pdf2.07 MBAdobe PDFView/Open
11_chapter7.pdf304.52 kBAdobe PDFView/Open
12_chapter8.pdf38.44 kBAdobe PDFView/Open
13_annexures.pdf906.06 kBAdobe PDFView/Open
80_recommendation.pdf51.54 kBAdobe PDFView/Open
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