Quality by design aided modified release non oral delivery systems of an antiinflammatory drug

Abstract

quotABSTRACT newline newlineQuality By Design Aided Nonoral Delivery System of An Anti- Inflammatory Drug newline newline newlineSubmitted By: newlineMulay Sushruta Rahul Rajashree newlineResearch Scholar, School of Pharmacy, RK University, VIVA Institute of Pharmacy, Virar, Maharashtra newline newlineSupervised By: newlineDr. Dharmik Mehta, newline newlineKey Words Curcumin, Hydrogel, Organogel, Design of Expert, Pluronic F-127, Microneedles, Lecithin, In Vitro Drug Release, Ex Vivo Drug Release, Quality Target Product Profile. newline newline newlineBackground: Curcumin has good potential as anti-inflammatory agent can used to reduce local inflammation in joints in conditions such as rheumatoid arthritis without affecting functioning of chondrocytes. Problem associated with curcumin is its very low permeation due to minimum absorption and rapid metabolism through skin. Therefore, there is a need to increase permeation of curcumin at local site and prolonging its effect on a longer time. newline newlineAim: Present study was aimed to prepare topical gel of curcumin in the treatment of inflammation by incorporating Quality by Design approaches and to study improvement in drug permeation through microneedles application. newline newlineExperimentation: Hydrogel of curcumin was prepared with Carbopol 934 newline newline newlineas gelling agent by using oleic acid as penetration enhancer. Hydrogels were evaluated with respect to different physicochemical parameters such as homogeneity, pH, Drug Content viscosity, Percent drug permeation after 2 hrs. and 8 hrs. Organogel of curcumin was formulated using Pluronic F- 127 as aqueous surfactant and lecithin as nonaqueous surfactant. Organogel formulations were optimised by 32 full factorization model to fix the Pluronic and lecithin concentrations to get maximum permeation of drug. Formulations were optimized by using DoE. Ex vivo skin permeation of drug was further studied with poration through solid microneedles. newline newlineResults and Discussion: Drug Permeation through hydrogel was very less and did not improve even after using pernetration enhancer. In organogel optimized batch containing 6.5% lecithin and Pluronic 20.6% was