Oxidative Stress Antioxidant Status and Vitamin D as Risk Factors in Hypertension

Abstract

Whole study population included 250 hypertensive cases and 250 controls. All newlineindividuals included in the study were submitted to: Complete history and physical newlineexaminations to evaluate exclusion criteria. Serum MDA was estimated by method of Jean newlineet al using trichloroacetic acid and thiobarbituric acid, SOD estimatrd by Marklund and newlinemarklund (1974) method, Catalase estimated by Aebi (1984) method and Vtamin D newlineestimated by ELISA method. Mean and standard deviation were calculated for serum MDA, newlineSOD, Catalase and Vitamin D. Statistical analysis was done using SPSS no. 20 and Microsoft newlineexcel. newlineDiscussion and results newlineA level of malonialdehyde (MDA) was found to be significantly higher (plt0.001) in newlinehypertensive cases and control. Activity of superoxide dismutase (SOD) and enzymatic newlineactivity of catalase were highly significant deceased (plt0.001) in hypertensive cases as newlinecompared to controls. Catalase levels in hypertensive cases were highly significant deceased newline(plt0.001) as compared to controls and level of vitamin D was highly significant decreased newline(plt0.001) in hypertensive cases compared to controls. newlineCONCLUSION newlineOur results suggest that patients with hypertension are vulnerable to oxidative stress newlineand have an impaired status of antioxidant capacity along with vitamin D deficiency. The newlinerole of oxidation mediated tissue damage in generation of hypertension in human is newlineevidenced by the lower blood levels of superoxide dismutase (SOD), catalase and vitamin D newlinewith higher malonialdehyde (MDA). Moreover there is still ongoing debate whether the newlineoxidative stress as observed by fluctuated oxidant and antioxidants parameters, in blood newlineleads to hypertension or is the consequence of it. Also, hypertension leads to decreased newlineantioxidant enzyme activities, which in turn, may contribute to oxidative stress related newlinediseases like atherosclerosis and cardiovascular diseases. newlineThus, further studies are necessary to delineate to the factors involved in the balance of newlineoxidants and antioxidants with deficiency of vitamin D in the pathogenesi